In some of the more affluent countries, corruption may be a major problem.

VOA: special.2009.11.28

So, many people have relatives they know of that have had to have their heart imaged -- heart disease is a major problem in the United States, and there's a good chance that they had Cardiolite given to them to help in that imaging process.

它被用在心脏成像中,很多人都有一些亲戚他们-,必须要做心脏成像，心脏病已经是美国的一个主要问题,而很有可能他们就要用到Cardiolite来成像。

麻省理工公开课 - 化学原理课程节选

This solves a major problem which I'm going to talk about just at the beginning of class here in a slide or two, is how to get DNA into cells?

这解决了我要讲到的一个主要问题,就是在这节开始的一两张幻灯片中要讲的,怎样将DNA导入细胞的问题

耶鲁公开课 - 生物医学工程探索课程节选

The loss of one oxygen tank should not have been a major problem.

VOA: special.2009.07.22

Undernutrition or hunger is a major world problem.

营养不良或说饥饿是一个世界性的大问题

耶鲁公开课 - 关于食物的心理学、生物学和政治学课程节选

The lack of clean drinking water is a major problem worldwide.

VOA: special.2010.04.05

Cigarette smoke is a major problem for asthma sufferers.

VOA: special.2010.09.07

Deforestation has traditionally been a major problem for farmers.

VOA: special.2010.04.13

"If you find that the road is not paved, or that the road is paved but breaks down because the corruption is so bad you do not get standards and quality, then you have got a major problem.

VOA: standard.2009.11.17

World Bank economist Louis Kuijs says he is not too concerned by strikes and says he does not see any signs that the industrial unrest will become a major problem for either social stability or for the Chinese and global economies.

VOA: standard.2010.06.24

Strada says he believes coalition forces are planning to launch a major bombing offensive in Afghanistan and the hospital in Lashkar Gah is a problem for them.

VOA: standard.2010.04.12