-
There's not actually chemical covalent bonds that are formed but it's a non-covalent interaction, usually dominated by hydrogen bonding.
所以配体和受体之间不生成共价键,这是一种非共价化合反应,它们通常以氢键相联
-
What are - this understanding of receptor-ligand interactions has been really the biological basis of much of the pharmaceutical industry.
受体-配体相互作用理论,现在已经成为很多,制药工业的生物学基础
-
They prevent the ligand from reaching its natural receptor, and so that antagonizes or inhibits the function of the natural ligand.
它们能够阻止配体与受体的结合,这样就拮抗或者说是抑制了配体的功能
-
Sometimes receptors, when they interact with ligands, create changes in what proteins are actually being produced by the cell.
有时受体与配体结合后,带来的变化实际是,决定细胞开始合成何种蛋白质
-
That ligand was one for which the cell had a receptor that further encouraged it to produce more of the ligand.
对于带有对应受体的细胞来说,这种配体能够刺激细胞产生更多的配体
-
What insulin is doing inside your body is acting as a ligand for insulin receptors which stimulate certain kinds of cellular responses.
胰岛素在体内的功能就是作为,胰岛素受体的配体,刺激产生某种细胞效应
-
We're going to take these general topics and talk about how they work in the nervous system and the immune system next time.
在下节课我会讲这些内容以及,配体-受体系统在神经系统和,免疫系统中的作用原理
-
In the case of a ligand-receptor, a chemical signal in the form of a concentration of ligand gets converted into a biochemical signal.
在配体-受体系统中,配体浓度这种化学信号,转化为生化信号
-
They bind sometimes better than the natural ligand does, but they don't create the right biological reaction.
结合的比天然配体和受体的的结合更紧密,但不能产生相同的生物效应
-
Depending on which cell you are you would call one the 'receptor' and the other the 'ligand'.
这取决于你将哪种细胞上的分子,称为受体,哪种称为配体
-
The rest of these examples refer to receptors as I've been describing them and ligands that are soluble and can move around the body.
我接下来要讲的有关受体,以及能游走于体内各处可溶性的配体
-
If a ligand comes and interacts with a receptor, it opens up; In the presence of this ligand, if the ligand goes away, it closes.
如果配体与受体相互作用,在配体存在的情况下通道打开,如果配体脱离,通道就关闭
-
The ligands are bringing some message, they transmit the message by binding to the receptor.
配体带有一些信息,它们通过与受体结合来传递这些信息
-
This is, maybe, the strangest because the ligand that stimulates the receptor is produced by the cell itself; so sometimes cells make signals that they receive.
它可能是最奇特的,因为激活受体的配体,是由细胞自身产生的,有时细胞产生让自己接受的信号
-
There's a diverse range of responses that might occur, but that response is initiated by this simple chemical process of a ligand binding to a receptor.
细胞对外界信号可能会发生不同的反应,但这些反应都源自,配体和受体结合这个简单的化学过程
-
Sometimes they inhibit by just preventing the ligand from interacting with its receptor.
有时它们只是,干扰配体和受体的相互作用
-
Here, there are receptors on one cell and the ligand that they experience is not a dissolved molecule, but actually a molecule that's attached to another cell.
这个细胞上有许多受体,与之结合的配体并非是可溶性分子,而是一个附着在其他细胞上的分子
-
If you think about receptor ligand system as an input into the cell.
如果将受体-配体系统看作,细胞的一种输入机制的话
-
Much of the work that pharmaceutical companies do in terms of searching for drugs is searching for new ligands that activate receptors and create biological responses inside cells.
很多制药公司新药筛选工作的主要内容,就是寻找能够激活受体的,新型配体,并在细胞内部产生某种生物学效应
-
So, they bind to the receptor - they occupy the receptor so now the natural ligand can't enter it but they don't create the same sequence of biochemical events.
因此,它们与受体结合,它们占据了受体,这样配体就进不来了,但这种结合无法诱发,真正的配体所能诱发的生化反应
-
Today let's think about it more generally as ligands and receptors.
今天我们讲讲普遍意义上的配体和受体
-
This terminology 'ligand' and 'receptor' you've probably heard before.
你们可能听过配体和受体这两个术语
-
In some cases it might be a ligand-gated ion channel.
有时受体可能是一个配体门控离子通道
-
Well, then you could imagine a cycle here where activation of the receptor is leading to production of more ligand, is leading to activation of the receptor and production of a ligand.
那么,你就能画出一个循环图,激活受体能导致,更多配体的生成,这些配体又会刺激受体生成更多配体
-
Focus on the concepts of receptors and ligands.
关注受体和配体的概念
-
So, these are receptors, for example, that bind the ligand and then liberate an enzyme which promotes some sort of reaction inside the cell, often it's kinases but doesn't have to be.
例如,这里是受体,与配体相结合,激活一种酶,这种酶能够催化细胞内的某些反应,这些酶通常都是激酶,但不全是
-
That infection occurs because of a ligand receptor interaction on the cell surface where the virus itself is the ligand and it takes advantage of a receptor that's expressed on the cell surface.
感染的发生是由于,配体与细胞表面受体相互作用,病毒是配体,它利用了在,细胞表面表达的受体
-
In this case, a receptor tyrosine kinase is a receptor molecule that binds a ligand at its surface outside the cell and initiates this enzyme activity - this kinase activity - and causes phosphorylation of another molecule.
在这个例子中,酪氨酸激酶受体可以,在细胞表面区域与配体结合,从而激发出,激酶的活性,使其能够磷酸化另一类分子
-
We're going to talk about this kind of non-covalent interaction more when we talk about the immune system, because one example of ligand and receptors that's important in the immune system are antigens - foreign molecules, and antibodies - molecules that we produce.
当我们讲到免疫系统的时候,会更详细地谈到这种非共价化合反应,因为在免疫系统中,一个重要的配体受体结合反应,就是抗原,即外源分子,与抗体,这个人体自身产生的分子结合
-
The cell that's producing the signal produces enough of the molecule so that it enters the bloodstream, it circulates throughout your body, eventually it reaches a cell at a great distance, which has a receptor for that ligand and the signal gets received.
发出信号的细胞产生信号分子,数量十分充足 能够进入到血液中,信号随着血液流遍全身,最终到达较远处的细胞,在这些细胞上有与配体配对的受体,信号被细胞接收
应用推荐