Well, what it is is easily enough explained despite the sort of difficulty and thorniness of the word.

虽然我们遇到过很多困难和挫折,但这个问题很容易解答。

耶鲁公开课 - 文学理论导论课程节选

They think, I'm really a smart investor, I figured it out,; it can reinforce the behavior until they get to maybe some terrible end.

他们会想我真是个聪明的投资人,我制定了如此有效的投资策略,这种想法使他们的自我膨胀加剧,直到他们遇到挫折或打击

耶鲁公开课 - 金融市场课程节选

He was looking very like happy which has suprised me, I mean, he's very boisterous where there isn't anything to set back by that at all, which I thought isn't.

他看起来很高兴，这一点,令我惊讶，我是说，他仍然充满活力,就像没有遇到挫折,但是总的来说，确实没什么挫折。

麻省理工公开课 - 电影哲学课程节选