It's not self-renewing, in that division of the zygote results in two daughter cells that are no longer the zygote anymore, they're down some pathway.

它是不会自我更新的,受精卵分裂后成了两个子细胞,而这两个子细胞就不再是受精卵了,它们沿着某种路径进行了分化

耶鲁公开课 - 生物医学工程探索课程节选

These signaling proteins play important roles in determining how many cells differentiate down particular pathways and they turn out also to be very useful for treating diseases of those pathways.

这些信号蛋白在决定特定分化路径上,有多少细胞在分化时起着重要作用,且在治疗疾病方面也很有用,同样也是利用这些机制

耶鲁公开课 - 生物医学工程探索课程节选