• This is a way for the immune system to recognize things that are going wrong inside the cell protected from antibodies.

    这是免疫系统识别,抗体不能识别细胞内病变的方法

    耶鲁公开课 - 生物医学工程探索课程节选

  • So, there are cells in your pancreas which recognize glucose levels and they secrete insulin in response.

    你的胰腺细胞能够,识别血糖水平,并分泌胰岛素作为反馈

    耶鲁公开课 - 生物医学工程探索课程节选

  • Other cells in the immune system recognizing that this is a foreign molecule, but is being presented in the context of a 'self' cell.

    免疫系统中的其他一些细胞,识别到它是非己物质,但它已经被识别为己方细胞

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  • It also has to have a promoter for the gene that the cells can recognize.

    另外还必须带有,受体细胞能够识别的启动子

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  • So having a place that the cell knows - where the cell knows how to replicate is important and so plasmids have an origin of replication.

    所以得有一个细胞识别的区域,能使细胞知道,怎样来复制 这很重要,因此质粒上带有一个复制起点

    耶鲁公开课 - 生物医学工程探索课程节选

  • These are cells that recognize a particular antigen, they're ready to differentiate into antibody.

    这些记忆细胞识别相应的抗原,它们已经准备好分化产生抗体

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  • These very small particles are able to specifically recognize certain kinds of cells.

    这些微小的小颗粒,可以识别特定种类的细胞

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  • When they receive the signal they make - they change in a very specific way and the cell can recognize this change that's occurred at the cell surface.

    当它们接收到信号之后,就会发生十分特殊的变化,细胞能够识别自身表面发生的这种变化

    耶鲁公开课 - 生物医学工程探索课程节选

  • So I can use the presence of those to identify cell populations.

    因此我可以利用这些蛋白的存在与否,来识别细胞

    耶鲁公开课 - 生物医学工程探索课程节选

  • We've learned how to identify and catalog cells according to the composition of proteins on the surface and those proteins that distinguish a cell are often called marker proteins.

    我们学会了如何按照表面的蛋白成分,来识别并分类细胞,而这些用来区别细胞的蛋白,通常称为标记蛋白

    耶鲁公开课 - 生物医学工程探索课程节选

  • One reason it's been harder to identify stem cells is that they're so rare; the other reason is that it's hard to identify the characteristics of them and it's taken many years to work this out.

    细胞难以识别的原因之一是,这些细胞很少,另一个原因就是,干细胞的特征性蛋白难以识别,我们花了好多年去解决这个问题

    耶鲁公开课 - 生物医学工程探索课程节选

  • How is your immune system going to recognize that this virus is there causing bad results if it's living inside of a cell and doing all its business inside a cell where antibodies can't get to it?

    你的免疫系统怎样才能识别,作恶多端的病毒呢,如果它隐藏在细胞中进行繁殖,而抗体又无法进入细胞,那该怎么办

    耶鲁公开课 - 生物医学工程探索课程节选

  • When these CD8 T-cells see your MHC1 together with an antigen that doesn't belong in you, it creates an immune response.

    当CD8 T细胞识别MHC1时,同时识别了不属于你的抗原,由此产生免疫反应

    耶鲁公开课 - 生物医学工程探索课程节选

  • They enter the cell after recognizing, they fall apart inside the cell, they reproduce their DNA, or their genetic material using host mechanisms.

    识别细胞后侵入之,它们在细胞内解体,复制自身的DNA,利用宿主的遗传来机制复制自己的DNA

    耶鲁公开课 - 生物医学工程探索课程节选

  • The immune system, some cells of the immune system, in particular this class of T-cells called CD8 cells have receptors which recognize MHC1.

    免疫系统,其中一些免疫细胞,特别是T细胞中的,CD8细胞含有可识别MHC1的受体

    耶鲁公开课 - 生物医学工程探索课程节选

  • Another subset of T-cells called T helper cells will recognize that signal by direct contact with it, and they will become activated and proliferate.

    另外一个T细胞的亚群是辅助性T细胞,辅助性T细胞识别与其接触的抗原信号,并被激活,开始增殖

    耶鲁公开课 - 生物医学工程探索课程节选

  • Now, for antibody production it is still a T-cell that recognizes the antigen presenting cell.

    现在,抗体的产生,仍是源于T淋巴细胞识别出抗原呈递细胞

    耶鲁公开课 - 生物医学工程探索课程节选

  • Because it has MHC-1, your MHC-1 on it, this T-cell recognizes that it's one of your cells but it has a foreign antigen associated with it.

    因为该细胞上有MHC-1,T细胞将这些细胞识别为自身细胞,但这些细胞带有异己抗原

    耶鲁公开课 - 生物医学工程探索课程节选

  • Well, the way that your immune system recognizes it is that all the cells of our body express a molecule on their surface, a membrane protein called the MHC1 complex.

    而免疫系统识别的方法是,身体内所有细胞在其表面表达一种分子,一种叫做MHC1复合体的膜蛋白

    耶鲁公开课 - 生物医学工程探索课程节选

  • Immune cells recognize it, and they recognize it by a very special form of receptor-ligand interaction where the ligand is MHC1 with the foreign antigen and the receptor is a receptor called the T-cell receptor complex.

    免疫细胞识别出染病细胞,通过一种特殊形式的,受体配体协作机制识别出来,其中的配体是同,外源抗原共同出现的MHC1,而这其中受体是T细胞受体复合体

    耶鲁公开课 - 生物医学工程探索课程节选

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