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When they do that they can actually engulf the bacteria in a process called phagocytosis and break them down into antigens.
免疫细胞确实是将细菌整个吞进了肚内,这一过程称为吞噬作用,并将细菌分解成小抗原
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This is a way for the immune system to recognize things that are going wrong inside the cell protected from antibodies.
这是免疫系统识别,抗体不能识别的细胞内病变的方法
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Memory cells are long lasting cells that remember this exposure and can respond very quickly on second exposure.
记忆细胞可以长时间记忆与抗原的接触,并在再次免疫中迅速做出应答
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Other cells in the immune system recognizing that this is a foreign molecule, but is being presented in the context of a 'self' cell.
免疫系统中的其他一些细胞,识别到它是非己物质,但它已经被识别为己方细胞
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Now, why do you need a cell mediated immune response if you have an antibody response?
为什么你还要有细胞免疫反应呢,你已经有抗体应答了啊
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Cell communication and immunology is what we're going to - is the topic for this week.
细胞通讯和免疫学,是我们本周要讲的主题
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That's a big problem and so can you protect these cells that you give to the recipient from attack by the recipient's immune system?
并且至关重要,那么你们想办法保护这些植入受体的细胞,使它们免受免疫系统的排异反应么
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Then, your muscle cells would start producing Hepatitis B surface antigen and your immune system recognizing that's a foreign protein would start responding to it.
于是,肌肉细胞将会,开始制造乙肝表面抗原,然后免疫系统就会识别出,那是外来蛋白质并且产生免疫应答
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Now, t-cells are also involved in humoral immunity but they're not the end result.
细胞也参与体液免疫,但它并不是体液免疫的最终应答结果
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Because it infects your cells and reproduces, your immune system responds much more vigorously.
由于它会感染你的细胞并且繁殖,所以你的免疫系统会有很强烈的反应
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So, what that really means, you know, from last week's lecture, is that the vaccine stimulates these particular cells in your immune system to give you immunity.
所以,这就意味着,通过上周的课程,你们知道,疫苗通过刺激免疫系统中的,特定细胞来使人获得免疫力
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We're going to - one of the reasons why you'll see why cell mediated responses are important is because antigens can appear in your body in different ways.
我们将--,细胞免疫如此重要的一个原因是,抗原能够以不同方式出现在体内
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Because on second exposure there's another population of cells that I haven't mentioned before that remain after the primary exposure and those are called memory cells, they're down here.
因为在再次免疫中,有另外一些细胞,我之前并没有提到过它们,在初次免疫结束后保留下来的细胞,被称为记忆细胞,它们在下面
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The immune response is directed at killing this cell.
免疫反应直接杀死了那个细胞
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It's the way, for example, that foreign molecules or antigens get presented to cells of your immune system in order to start the process of making an immune response, so sometimes a cell/cell interaction.
通过这种方式,外源分子,或者说抗原,进入到免疫系统的细胞中后,就会开启免疫反应过程,有时候就是细胞之间的相互作用
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The reason is that because of the ways that different microorganisms take the ways the different microorganisms reproduce and damage cells and tissue within your body, you need different ways to respond to them effectively.
因为不同的微生物以不同的方式,以不同的方式繁殖,和损害体内的组织和细胞,你需要多种有效的免疫反应来对付它们
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Usually the cellular means that they get rid of is that instead of an antibody being produced, you activate a population of cells that will specifically go and hunt down the foreign antigen, or more commonly, cells that contain the foreign antigen.
通常细胞免疫意味着,不用生成抗体就能清除抗原,你激活了一个细胞类群,这一类群能够,并杀伤外源抗原,或者更常见的是,杀伤含有外源抗原的细胞
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But this antigen presenting cell is more likely a professional antigen presenting cell, or a subset of cells of your immune system that are specialized in ingesting foreign particles and displaying their contents to the rest of the immune system.
但这种抗原呈递细胞更加类似于,专职抗原呈递细胞,或者是体内免疫细胞中的一个亚群,专门从事吞噬异己物质,并告知免疫系统的其他细胞的工作
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So, these memory cells are a way that your immune system keeps track of antigens that it's been exposed to for even if maybe the plasma cells that were producing antibody in response to the initial exposure have died and disappeared.
所以,这些记忆细胞,是人体免疫系统记忆抗原的一种方法,即使由浆细胞产生的抗体,在初次免疫应答中全部被消灭,记忆细胞仍然能迅速分化为抗体分泌细胞
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We're going to talk about those in more detail in a couple of weeks when we talk about the immune system because these are the cells that perform and regulate the functions of our immune system that protect us from disease.
在后几周的有关免疫的课程上,我们会详细说明的,因为我们免疫系统的功能,要依靠这些细胞去完成和调节,它们使我们免受疾病侵害
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Or maybe I could donate bone marrow and those stem cells could be given to other people in the same way that blood can be given to other people by matching and making sure that immunologically my cells were compatible with you; there's a lot of interest in that.
或者我可以捐献骨髓,而那些干细胞,可以使用和输血同样的方法,通过配型来确认我的免疫细胞和你的匹配,从而把我的干细胞,输入给你,这里面有很多有趣的东西
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Here, I've just picked a couple of the pictures that I showed you last time when we were talking about cell communication in the immune system, What happens after the vaccine is introduced into your body is that it initiates cellular events.
我挑选了,我上次给你们展示的几幅图片,当我们讨论到,免疫系统中的细胞沟通时,讲到过当人体接种疫苗之后,能够触发,细胞活动
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The other part of the adaptive immune system is the cell mediated immune system and this is an immune where that doesn't involve antibodies but involves cells that are activated in response to a foreign antigen and that utilize cellular means to get rid of it.
获得性免疫系统还包括,细胞免疫,这一免疫反应不包含抗体,但包含可以被激活来应答,并清除外源抗原的免疫细胞
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So, those wrong proteins get presented on MHC1 and your immune system can kill the cell because it's a tumor cell.
所以 当这些错误的蛋白,同MHC1一起被呈递,你的免疫系统就可以消灭这些肿瘤细胞
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The main effector cells in cell mediated immunity, the cells that do the main business are called T-cells.
细胞免疫中的主要效应细胞,即发挥主要作用的细胞是T细胞
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What happens when they're activated is they start to reproduce, they make more and more, and more B-cells.
激活后,免疫细胞开始增殖,B细胞变得越来越多
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The immune system, some cells of the immune system, in particular this class of T-cells called CD8 cells have receptors which recognize MHC1.
免疫系统,其中一些免疫细胞,特别是T细胞中的,CD8细胞含有可识别MHC1的受体
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So, that's antigen presentation to this population of cells called cytotoxic T-cells, Tc, a subset of the class of T-cells in the immune system.
这些细胞被呈递给另一种细胞,这些细胞被称为细胞毒性T细胞,是免疫系统中T淋巴细胞的亚群中的一种
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For example, HIV enters cells of the immune system by binding to a receptor called CD4.
比如,HIV通过与CD4的受体结合,进入到免疫系统细胞中
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Here's where the intelligence of the immune system comes in, is that these cytotoxic T-cells that are generated only kill cells that have this signal on it.
免疫系统的聪明之处就在此,这些细胞毒T细胞,只能杀死具有特殊标记信号的细胞
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