Genetic scans for disease predictions, and we talked about one way you might do that using gene chips.

基因扫描技术可用于预测疾病,我们讨论的基因芯片技术是其中的一种

耶鲁公开课 - 生物医学工程探索课程节选

If we looked at all 30000, genes that were important in each individual how do you pick out which ones are important for a particular disease?

如果我们检查人体中,所有三万个至关重要的基因,要怎样从中找出,导致某种疾病的特定基因呢

耶鲁公开课 - 生物医学工程探索课程节选

Usually this is a disease that's caused by a defect in a single gene.

通常在疾病是由,单基因缺陷引起时才可行

耶鲁公开课 - 生物医学工程探索课程节选

One way is to replace a gene that's defective in a disease.

其中之一是置换,导致某种疾病的缺陷基因

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If you had genetic scans that were available for disease prediction, do you want to know everything that's going to happen to you in terms of susceptibility to disease?

如果我们有基因扫描技术,可以预测疾病,你是否愿意知道,你都可能会得什么病

耶鲁公开课 - 生物医学工程探索课程节选

One of the ways that it's used is to take the fertilized egg from an animal, a mouse, usually it's a mouse and inject in a vector that contains a gene that is involved in human disease of some sort.

其中一种应用就是,从动物,一般是老鼠体内取出受精卵,注入某种质粒,这种质粒带有与某些人类疾病相关的基因

耶鲁公开课 - 生物医学工程探索课程节选

These are ways to stop a gene from being expressed, and there turns out there's lot of applications in that, lots of diseases result from the unwanted expression of certain kinds of genes and cancer is probably the best example of that, but there are many.

有些方法能够终止基因的表达,而这些方法也经证实有广泛的应用,有很多疾病是源于基因的异常表达,而癌症大概是这种情况最好的例子,但还有很多其他的

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Or what - and often it's not going to be just one gene, it's going to be combinations of genes, and how do you predict the fate of the individual based on all of the genes that you know to be involved in progression of a certain disease.

有时候甚至都不仅仅是一个基因的问题,引发疾病的是一些不同基因的组合,并且怎样基于,导致某种特定疾病的所有基因,来预测一个人未来是否会患这种疾病呢

耶鲁公开课 - 生物医学工程探索课程节选

I want you to look at this picture, read the little bit about gene - control of gene expression - that's in the book, know that it's a big topic, that we're not going to talk about it except we're going to talk about some examples where control of gene expression can be exploited in order to treat diseases, for example. So I'll see you on Thursday.

所以我希望你能看一下这张图,读一些,教材里基因调控的章节,这是个很大的话题,我们不会进一步深入去探讨,但一些基因调控,用以治疗疾病的例子,我们可能还会在之后的课程中讲到,那我们周四见了

耶鲁公开课 - 生物医学工程探索课程节选