• So, now you have a single molecule, very large molecule, with not just two binding sites but with ten binding sites.

    所以如果你体内有一个细胞,一个体积很大的细胞,细胞表面不只有两个抗原结合位点,而有十个抗原结合位点

    耶鲁公开课 - 生物医学工程探索课程节选

  • The advantage of this is that now you have four binding sites for antigen instead of just two.

    这样的好处是一个抗体上,有四个抗原结合位点而不仅仅是两个

    耶鲁公开课 - 生物医学工程探索课程节选

  • So, these are better at binding to antigen because they have more binding sites on them.

    连接抗体是对付抗原的有效方法,因为抗体表面将会有更多的抗原结合位点

    耶鲁公开课 - 生物医学工程探索课程节选

  • They also have binding sites for antigen, but they are sort of two IgG type molecules bound together by another peptide chain.

    同样IgA抗体表面也有与抗原结合位点,但它们就像两个IgG型分子,通过肽链相互连接

    耶鲁公开课 - 生物医学工程探索课程节选

  • The IgM is really five IgG-type molecules that are linked together through disulfide bonds, such that their FC portions are all pointing in and their antibody binding portions are all pointing out.

    gM是由五个IgG分子组成的,IgG分子之间通过二硫键连接,免疫球蛋白尾部的FC片段都指向内侧,而抗体的抗原结合位点都指向外侧

    耶鲁公开课 - 生物医学工程探索课程节选

  • Well, one way to think about is they have more antigen binding sites and so they're going to be more efficient at neutralizing the pathogen on a per-molecule basis than IgG is.

    可以这么考虑,因为IgM表面有更多的抗原结合位点,所以相对于IgG,IgM在分子层面上,能够更为有效地与病原体结合

    耶鲁公开课 - 生物医学工程探索课程节选

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