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The advantage of this is that now you have four binding sites for antigen instead of just two.
这样的好处是一个抗体上,有四个抗原结合位点而不仅仅是两个
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One is there's no lag period, notice that antibody levels start rising right away after the second exposure.
第一是没有迟滞期,请注意,抗体浓度迅速上升,在第二次接触抗原时
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So, I have a bacteria infection, stimulates my immune system, I start making antibodies that bind to an antigen specific to that bacteria.
所以 如果我被细菌感染了,我的免疫系统被激活,开始制造抗体,这些抗体结合到细菌特异性的抗原上
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So, these are better at binding to antigen because they have more binding sites on them.
连接抗体是对付抗原的有效方法,因为抗体表面将会有更多的抗原结合位点
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Again, these are antibodies that are specific to that antigen or vaccine that we introduced.
我再说一次,这些抗体针对于,我们所接种的抗原或疫苗特异产生
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We're thinking about the particular antibody that binds to this antigen that you're exposed to.
现在,我们考虑一种特殊的,与你所接触的抗原相结合的抗体
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These are cells that recognize a particular antigen, they're ready to differentiate into antibody.
这些记忆细胞可识别相应的抗原,它们已经准备好分化产生抗体
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The antibodies they make are all specific to the antigen that stimulated them.
它们制造的抗体,对激活它们的抗原来说都是特异性的
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I realize that this thinking about antigen, antibody combinations and the mathematics of how strongly an antibody binds to a specific antigen, is maybe something that's new to you.
我觉得这些关于 抗原抗体结合,以及,抗体如何强有力地结合抗原的问题,对你们来说很新鲜
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This is a very potent molecule for binding to antigen.
这个抗体分子就具有强大的抗原结合能力
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They bind to the antigen that stimulated their production.
它们结合在那些,激活了抗体产生的抗原之上
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How do they recognize it?
抗体是怎样识别抗原的呢
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So, our bodies are capable of making antibodies that are tuned for all the potential antigens that we come into contact with, That's amazing that we have this capacity to respond and you respond only when needed.
所以 我们的身体具有制造抗体的能力,这些抗体对于各种潜在抗原具有特异性,我们具有只在需要时做出,免疫反应的能力 这太让人惊叹了
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We're going to talk a lot about antibodies over the next week or so, but antibodies are specialized proteins that, as you know, are designed to bind to antigens or foreign molecules inside the body.
我们将会在接下来的几周,讲许多关于抗体的内容,抗体是一种特殊蛋白质,众所周知,抗体用于结合身体内的抗原和外源分子
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We're going to talk about this kind of non-covalent interaction more when we talk about the immune system, because one example of ligand and receptors that's important in the immune system are antigens - foreign molecules, and antibodies - molecules that we produce.
当我们讲到免疫系统的时候,会更详细地谈到这种非共价化合反应,因为在免疫系统中,一个重要的配体受体结合反应,就是抗原,即外源分子,与抗体,这个人体自身产生的分子结合
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Usually the cellular means that they get rid of is that instead of an antibody being produced, you activate a population of cells that will specifically go and hunt down the foreign antigen, or more commonly, cells that contain the foreign antigen.
通常细胞免疫意味着,不用生成抗体就能清除抗原,你激活了一个细胞类群,这一类群能够,并杀伤外源抗原,或者更常见的是,杀伤含有外源抗原的细胞
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If there were just-- if you were trying to create a positive reaction of antigens and it showed up naturally wouldn't it create this reaction anyway in terms of your body would create antibodies like the secondary response volume to antibodies?
如果这里仅有,如果在自然条件下,尝试建立抗原的阳性反应,抗体这是否会像这样反应,以你身体为例,你的身体是否会产生,同二次免疫一样的抗体浓度
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So, these memory cells are a way that your immune system keeps track of antigens that it's been exposed to for even if maybe the plasma cells that were producing antibody in response to the initial exposure have died and disappeared.
所以,这些记忆细胞,是人体免疫系统记忆抗原的一种方法,即使由浆细胞产生的抗体,在初次免疫应答中全部被消灭,记忆细胞仍然能迅速分化为抗体分泌细胞
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One of the things that I didn't mention before is that when you get this primary response and then the secondary response, if you looked at the antibodies that are generated during the primary response, again we're only looking at antibodies that bind to the particular antigen or vaccine that we have used for the priming.
还有一点我之前没有提及,当你获得初次免疫,以及再次免疫之后,如果你仔细观察抗体,观察那些在初次免疫中生成的抗体,这次我们同样只是观察抗体,那些与我们在初次免疫中所用到的,特定抗原或疫苗相结合的抗体
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One thing I do want you to remember is that IgM class antibodies are the antibodies produced on first exposure.
我希望你们记住的一点是,IgM类抗体是人体在,第一次接触抗原时产生
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They also have binding sites for antigen, but they are sort of two IgG type molecules bound together by another peptide chain.
同样IgA抗体表面也有与抗原结合位点,但它们就像两个IgG型分子,通过肽链相互连接
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The antibody that they stimulate is antibody that's specific to this antigen that was presented earlier.
这些由辅助性T细胞,刺激增殖产生的抗体是,对应之前出现的抗原而产生的
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They come from B-cells, they come from B-cells that are activated with a specific antigen.
抗体来自于B细胞,它们来自于被特别的抗原所激活的B细胞
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Most of them are of the class IgM; IgM antibodies are produced on first exposure.
其中大部分抗体都属于IgM,IgM在机体首次接触抗原时产生的
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Now, for antibody production it is still a T-cell that recognizes the antigen presenting cell.
现在,抗体的产生,仍是源于T淋巴细胞识别出抗原呈递细胞
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Because at the end of the Y, there's a special region of the antibody, the antigen-binding region, that is highly tuned for binding to the antigen that stimulated them.
因为Y形抗体的末端,是抗体上非常特殊的一个区域,即抗原结合区域,这一区域高度特异性地,用于结合激活免疫的抗原
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In the case of the helper cells they stimulate a specific population of B-cells to mature into antibody producing cells, and that antibody is generated against the antigen that stimulated it.
以辅助性T细胞为例,辅助性T细胞刺激特定的B细胞,使这些细胞成长为抗体分泌细胞,抗体分泌细胞产生大量的抗体,以消灭大量增殖的抗原
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The IgM is really five IgG-type molecules that are linked together through disulfide bonds, such that their FC portions are all pointing in and their antibody binding portions are all pointing out.
gM是由五个IgG分子组成的,IgG分子之间通过二硫键连接,免疫球蛋白尾部的FC片段都指向内侧,而抗体的抗原结合位点都指向外侧
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