One that was developed a number of years ago but has been perfected and refined in recent years with very, very good research.

该概念很多年前就已经提出了,但在近年通过高水平的研究才被改进完善

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In fact there's research-- for example, this was done with internists, doctors, who are giving a very difficult, very difficult question connected to a liver problem that an individual patient had.

实际上有这样一项研究-,在内科医生，医生中间进行，向他们提出一个，与肝脏问题有关的很困难的问题,那是一个病人的病症。

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