• Once you have a difference that occurs, two cells are difference, those differences can propagate as the cells continue to divide.

    一旦产生差异,产生两个不同的细胞,这些差异会伴随着,细胞分裂过程代代相传

    耶鲁公开课 - 生物医学工程探索课程节选

  • It's really just the result of the virus dividing within cells of your skin, and producing a lot of dead cells.

    这便是病毒在皮肤细胞内部,分裂的结果,这个过程会产生大量的死亡细胞

    耶鲁公开课 - 生物医学工程探索课程节选

  • That's shown schematically here, let me talk about the bottom diagram first, which shows the process of mitosis.

    在此我们图解了这一过程,我先从下面图表里的,有丝分裂过程讲起

    耶鲁公开课 - 生物医学工程探索课程节选

  • This process of cell proliferation or cell division is, of course, very important during development of an embryo.

    细胞增殖和分裂过程,在胚胎发育中至关重要

    耶鲁公开课 - 生物医学工程探索课程节选

  • As division happens and the developing organism acquires more and more cells, individual cells become differentiated, they become more and more like their final mature form.

    分裂过程不断发生,以及发育中的有机体对更多细胞的需求,细胞个体便逐渐分化,它们越来越接近成熟细胞的样子

    耶鲁公开课 - 生物医学工程探索课程节选

  • Well, what if this division takes place in an environment where there's one kind of extra cellular matrix here and another kind of extracellular matrix here?

    那如果在细胞分裂过程中,两个子细胞的细胞外基质不同,会对它们产生什么影响

    耶鲁公开课 - 生物医学工程探索课程节选

  • The size of the cells could be different; maybe mitosis is asymmetrical in some way so that one of the cells ends up being bigger than the other.

    细胞大小可能会不同,也许有丝分裂过程是不对称的,致使子细胞一个大一个小

    耶鲁公开课 - 生物医学工程探索课程节选

  • We talked about last time that part of the process of going from this single cell to multi cellular many celled organisms like we are is cell division.

    我们上节课说过,从一个单细胞分裂形成大量细胞,构成的器官的过程,叫做细胞分裂

    耶鲁公开课 - 生物医学工程探索课程节选

  • They're not chromosomal differences because this is the ordinary process of mitosis.

    它们的染色体没有任何变化,因为这是正常的有丝分裂过程

    耶鲁公开课 - 生物医学工程探索课程节选

  • What is the difference that's generated during an asymmetric cell division?

    不对称分裂过程中,到底产生了怎么样的变化

    耶鲁公开课 - 生物医学工程探索课程节选

  • It goes - going through this process of amplifying divisions, every division increasing the number of cells by a factor of two and these cells becoming more differentiated around the way.

    它经历了一系列扩增性的分裂过程,每次分化,细胞数目都翻一番,而在此过程中细胞分化得更成熟

    耶鲁公开课 - 生物医学工程探索课程节选

  • Or it can the kind of change we talked about before, where during division there are some chemicals that are trapped in one cell and not in the other, and that could lead to a difference we already talked about.

    可能是我们之前说过的,在分裂过程中可能发生的,不对称分裂的现象,并导致我们已经讲过的某些不同

    耶鲁公开课 - 生物医学工程探索课程节选

  • The same thing with these cells here, as these cells undergo continual divisions, they're changing in ways that make them mature, that make them more like the mature cells of the nervous system, for example, if that's where they end up being but they're losing potential as they go through that differentiation process.

    细胞也是这样,在连续分裂过程中,它们愈发成熟,比如说,变得越来越像,神经系统细胞,如果它们最终将构成神经系统的话,那它们在分化的过程中,就失去了许多潜能

    耶鲁公开课 - 生物医学工程探索课程节选

  • If mitosis occurs the way that it's supposed to, the DNA that's in each of these cells is the same.

    如果有丝分裂过程按部就班地进行,那所有细胞的DNA都是相同的

    耶鲁公开课 - 生物医学工程探索课程节选

  • Several things happen during mitosis, first, when a cell enters the process of mitosis it already has twice the DNA that it needs.

    有丝分裂中有几个重要的步骤,首先,当细胞进入有丝分裂过程,细胞中已含有两倍于其正常所需的DNA

    耶鲁公开课 - 生物医学工程探索课程节选

  • There could be differences in the physics of cell division, this process of separating into two cells such that even though they both have the same chromosomes, they both have the same DNA content, maybe one of the cells entraps something that's different than the other cells.

    细胞分裂过程中的确可能会产生差异,在分裂为两个细胞的过程中,尽管两个子细胞含有相同的染色体,含有相同的DNA组成,但也许其中一个细胞,截留了和其他细胞不同的物质

    耶鲁公开课 - 生物医学工程探索课程节选

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