• The best way to label this DNA is by designing probes or labels that hybridize with specific sequences that you're interested in.

    最好的标记方法是,设计出能与你感兴趣的,特定基因序列杂交的,分子探针或标签

    耶鲁公开课 - 生物医学工程探索课程节选

  • Well, one way you can get it is by mixing the gene with lipids, with lipid molecules.

    一种方法可以将基因与脂质体混合,同脂类分子混合

    耶鲁公开课 - 生物医学工程探索课程节选

  • These kinds of molecules which activate genes, they're activating the process of transcription.

    这种分子能够激活基因,激活了转录过程

    耶鲁公开课 - 生物医学工程探索课程节选

  • When transcription happens and it turns out that there's a whole biology associated with this, including molecules that are floating around inside your cells called transcription factors, and their job-- they are molecules that are about particular genes and what some of the sequences and are able to turn on those genes inside cells, to make them transcribe.

    研究证明,当细胞转录时,还有与之相关的一整套生物机制在运作,包括一种在你细胞中飘浮着的,称为转录因子的分子,它们的工作就是,它们知道该转录哪一段基因,该转录哪一段序列,然后把这些细胞中的基因激活,进行转录

    耶鲁公开课 - 生物医学工程探索课程节选

  • They're not whole genomes, but they're some small piece of DNA maybe the size of a protein.

    不是整个基因组,而是小的DNA片段,但也许与蛋白质分子一样大

    耶鲁公开课 - 生物医学工程探索课程节选

  • There are molecules in cells that give the DNA the signal that it's time to transcribe and express a gene, those are called transcription factors, we'll talk about them a bit later.

    在细胞中有些分子能够,给DNA发出信号告诉它,是时候转录和表达某基因了,这些分子叫做转录因子,晚些时候我们会讲它们

    耶鲁公开课 - 生物医学工程探索课程节选

  • If you can interfere with any stage in RNA processing you can stop a gene from being expressed and this is a very hot topic in molecular biology now and human therapeutics.

    如果你能干扰RNA加工的任何一个阶段,你就能阻止一段基因的表达,这也是当今分子生物学,和新型疗法中非常热门的话题

    耶鲁公开课 - 生物医学工程探索课程节选

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