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I mentioned earlier, we thought about receptors as being these blocks and membranes but there are different families of receptors.
我之前讲过,我们把受体看做一类,固定在细胞膜上的分子,但受体有许多不同家族
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These are molecules that exist naturally in cell membranes and are activated by certain enzymes and kinases generated by receptors.
这些分子存在于细胞膜表面,能被受体激活的某种酶或激酶所活化
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That general class of molecules is called receptors and its shown here just as a block of material living in the cell membrane.
这一类分子叫做受体,在这里看起来就像是,生活在细胞膜内的物质
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When they bind, they produce some change in the receptor molecule which is experienced inside the cell.
当它们结合后,会使受体分子发生改变,这个过程发生在细胞内部
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Depending on which cell you are you would call one the 'receptor' and the other the 'ligand'.
这取决于你将哪种细胞上的分子,称为受体,哪种称为配体
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Here, there are receptors on one cell and the ligand that they experience is not a dissolved molecule, but actually a molecule that's attached to another cell.
这个细胞上有许多受体,与之结合的配体并非是可溶性分子,而是一个附着在其他细胞上的分子
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This is a new concept, receptors don't have to be these molecules on cell surface, there can be receptors that exist in other places within the cell.
这是一个新概念,受体分子不一定只存在于细胞表面,它们也可以存在于细胞内其它地方
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So, it doesn't need to bind to a receptor on the surface of the cell in order to work because the molecule can actually enter the cell directly.
所以无需与细胞表面受体相结合来起效,因为这些分子能直接进入细胞
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Now, the other thing to keep in mind is that for any cell there's not just one receptor on the cell, there are thousands, or hundreds of thousands of receptors.
我们要记住的另一点是,在细胞表面,不仅仅只有一个受体,而是有成千上万甚至更多的受体分子
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For now, just picture it in this simple way as a molecule, usually a protein, that's embedded in the cell membrane and many receptors have a part of them that is extracellular.
现在,我只把这种分子图示出来,受体通常是一种蛋白质,它们镶嵌在细胞膜上,很多受体还有部分结构露在细胞外
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Sometimes second messengers collect signals from a variety of different receptor systems, translate them into one kind of internal change, and the cell then just has to know about that one thing changing.
第二信使分子能够收集,来自不同受体系统的信号,将它们转化为同一种细胞内在的变化,这样细胞就只需对一种变化作出反应
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Now, in this cartoon here I've shown a variety of different receptors just to show just to remind you of the different families of receptor molecules that could be involved in receiving and translating a signal.
这个动画中,我向你们展示了各式各样的受体,为了让你们记住不同族的受体分子,它们都涉及信号的接受和翻译过程
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It refers to usually 'receptors' that are fixed in a cell, on a cell membrane, and 'ligands' which are dispersed throughout the body and free to diffuse around, and occasionally will find the cell.
受体这个词通常代表了,固定于细胞表面的分子,而配体分散于体内各处,能够自由扩散,它们偶尔会与细胞邂逅
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There are 100 of these molecules, when a receptor gets activated a kinase activity gets activated, the kinase acts on the protein, the protein gets switched on, something new starts to happen inside the cell.
有一百个这样的分子,当受体被激活,激酶被激活后,激酶作用于蛋白,使蛋白活化,细胞中就会发生一些新变化
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We're going to talk about this kind of non-covalent interaction more when we talk about the immune system, because one example of ligand and receptors that's important in the immune system are antigens - foreign molecules, and antibodies - molecules that we produce.
当我们讲到免疫系统的时候,会更详细地谈到这种非共价化合反应,因为在免疫系统中,一个重要的配体受体结合反应,就是抗原,即外源分子,与抗体,这个人体自身产生的分子结合
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The receptor for estrogen is a special molecule called a DNA binding factor.
雌激素受体是一类特殊的分子,叫做DNA结合因子
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It gets produced in response to a signal so there's a binding of a ligand to a receptor, the enzyme that does this conversion is activated and more cycle AMP is released.
这类分子的产生是对信号做出的一种反应,当配体和受体结合时,催化这种转化过程的酶被激活,更多的cAMP释放出来
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