• We talked about base pairing and how that leads to this process of hybridization or very specific matching between complimentary strands.

    我们讲了碱基配对,以及它们如何引起杂交过程,或者说,互补链之间的特异配对

    耶鲁公开课 - 生物医学工程探索课程节选

  • The correct complement is made because of these principles of Watson-Crick base pairing that we talked about before.

    剪接配对的正确性源自,沃森克里克碱基互补配对原则的作用,这我们讲过的

    耶鲁公开课 - 生物医学工程探索课程节选

  • I just give you one of those, right, because you could write down the other one because you know the other complimentary sequence from base pairing?

    我只写了一条链的序列,因为你们能够写出另一条,因为你们根据碱基配对,就能推测出互补链的序列

    耶鲁公开课 - 生物医学工程探索课程节选

  • I told you that the fidelity is very high.

    互补配对的一致性是非常高的

    耶鲁公开课 - 生物医学工程探索课程节选

  • This notion of complementary strands is very important.

    这个双链互补配对的概念非常重要

    耶鲁公开课 - 生物医学工程探索课程节选

  • Translation occurs by a special kind of polymerization where these transfer RNA's operate by Watson-Crick base pairing.

    翻译过程是一种特殊的聚合过程,当tRNA按照,沃森克里克碱基互补配对原则进行配对

    耶鲁公开课 - 生物医学工程探索课程节选

  • It exists in a double stranded form where every strand is matched by its complement.

    这种碱基配对存在于DNA双链中,每条单链都与其互补链,通过这个原则配对组合

    耶鲁公开课 - 生物医学工程探索课程节选

  • It has to do with the nature of this complementary binding between double stranded DNA and the fidelity of this base pair matching in forming stable DNA molecules.

    这些特性能从根本上解释,为何DNA双链的碱基能互补配对,以及在形成稳定的DNA分子结构时,碱基互补配对为何具有一致性

    耶鲁公开课 - 生物医学工程探索课程节选

  • If I'm talking about two DNA strands and they differ only in one or two base pairs they won't be exact complements and they won't form this double helix.

    假设有两条DNA单链,有一两个碱基不能配对,它们就不能完全互补,也无法形成双螺旋形结构

    耶鲁公开课 - 生物医学工程探索课程节选

  • That's because you have to satisfy this base pair matching in order to have hydrogen bonding in each of the struts of the ladder in order to form a stable structure.

    NA双链要满足互补配对原则,以使碱基对之间,形成氢键,从而形成稳定的双链结构

    耶鲁公开课 - 生物医学工程探索课程节选

  • Well you do that by this Watson-Crick base pairing, so I know if I have I know what messenger RNA to make from that because I have to satisfy these base pairing rules.

    依据的是沃森克里克碱基互补配对原则,如果给我一个ACGCGA的序列,就能知道转录出的mRNA会是什么,因为我必须满足碱基配对原则

    耶鲁公开课 - 生物医学工程探索课程节选

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