That's one of the beauties of proteins as working molecules is that their structure can be changed by subtle means.

蛋白质作为一种生物活性分子,其优势之一是,能够通过精细的方法改变其结构

耶鲁公开课 - 生物医学工程探索课程节选

It generates a kinase activity which leads to phosphorylation of the protein.

它产生了一种激酶活性,导致了受体蛋白的磷酸化

耶鲁公开课 - 生物医学工程探索课程节选

It's a gene that allows you to deliver a drug that's not active but the gene causes that active - that inactive drug to be converted into an active form that kills the cell.

这一方法利用该基因激活,另一种已经导入细胞的非活性药物,来杀死肿瘤细胞

耶鲁公开课 - 生物医学工程探索课程节选

Insulin, the ligand binds to its receptor, creates a change through a kinase activity that's exposed, which leads to other biochemical changes, which leads to a change in cell behavior - in this case the cell behavior is that more glucose transporters are brought to the membrane and more glucose can enter the cell.

胰岛素,一种能够与受体结合的配体,通过其暴露出的激酶活性引起的变化,导致了其它后续生化变化的发生,进而使细胞行为发生改变,这个例子中的细胞行为就是,更多的糖载体被带到细胞膜表面,这样更多的糖分子进入到细胞内部

耶鲁公开课 - 生物医学工程探索课程节选