One of the biggest challenges has been the detection of CNVs.
其中最大的问题是基因克隆数变异的检测。
Even so, scientists have been able to link CNVs to a handful of complex diseases.
尽管如此，科学家们已经将CNVs和一些复杂的疾病联系起来。
Some CNVs are common, but others are rare or occur with low frequency among humans.
有些拷贝数变异是很常见的，但还有一些则在人类中极少发生或是发生的频率较低。
We're really only looking at the tip of the iceberg in terms of how CNVs cause disease.
在研究拷贝数变化如何引起疾病中，我们看到的仅是冰山一角。
The results show that at least 10-20% of heritable variation in gene activity is due to CNVs.
研究结果表明至少有10%—20%的基因活性方面的遗传变异归功于变异基因拷贝数方面的因素。
"We are moving in a direction where CNVs are playing a role in a number of different neurobehavioral conditions," Cuccaro said.
他认为，“基因拷贝数异变在各类精神病症中有很大作用，我们正在努力了解其运行机理。”
However, Dr. Jacquemont and his colleagues also found that damaging CNVs were more likely to be inherited from a child's mother than from his or her father.
然而，Jacquemont医生和他的同事同样也发现受损的CNVs遗传于母亲的可能性大于他或她的父亲。
Sometimes cells make the correct amount anyway; other times CNVs affect DNA regions that regulate the expression of still other genes, making the problem more complicated.
有的情况下，细胞不管怎样还是维持正确的量；别的情况下，CNVs对调控另外的基因表达的DNA区域有影响，使问题更加复杂。
Sometimes cells make the correct amount anyway; other times CNVs affect DNA regions that regulate the expression of still other genes, making the problem more complicated.
有的情况下，细胞不管怎样还是维持正确的量；别的情况下，CNVs对调控另外的基因表达的DNA区域有影响，使问题更加复杂。
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