目的：筛选青藤碱凝胶剂的最佳处方。
目的：研究青藤碱对慢性肾炎的药理作用。
Objective: To study the pharmacological action of sinomenine on chronic nephritis.
盐酸青藤碱是其盐酸盐。
The hydrochloric acid cocculus tunbergii alkali is its muriate.
生物转化为青藤碱的结构改造提供了研究方向。
Biotransformation is going to provide a new research direction for structural modification of sinomenine.
观测不同剂量青藤碱干预肿瘤细胞凋亡的效果。
结果青藤碱组CIA大鼠滑膜细胞的凋亡数明显增加。
Results Sinomenine could induce apoptosis of synoviocytes in CIA rats.
方法采用膜控技术，离心造粒法制备盐酸青藤碱控释微丸。
Methods Membrane controlled-release technique and centrifugal coating pelletization were used to prepare sinomenine hydrochloride controlled release pellets.
采用膜控技术，离心包衣造粒法制备了盐酸青藤碱控释微丸。
By using membrane controlled-release technique and centrifugal coating pelletization, sinomenine hydrochloride controlled-release pellets were prepared.
应用蔗糖间隙法研究青藤碱对离体兔颈上交感神经节的作用。
The effect of Sin on the transmission of the impulses through isolated rabbit superior cervical sympathetic ganglia in comparison with that of curare by the sucrose - gap method was studied.
探讨采用血液微透析技术研究青藤碱药动学的可行性和优越性。
To explore the feasibility and advantages of blood microdialysis technique for the pharmacokinetic study of sinomenine.
目的考察大鼠皮肤角质层对青藤碱脂质体贴剂透皮吸收的影响。
Objective To study the effect of skin stratum corneum on transdermal absorption characteristic of Sinomenine Liposome Patch.
结论：纯白盐酸青藤碱为最佳晶型，为该原料药制剂生产提供参考。
CONCLUSION the pure white sinomenine hydrochloride is the best crystal, it can be referenced for production.
结论青藤碱治疗类风湿性关节炎的机制可能与诱导滑膜细胞凋亡有关。
Conclusi on the mechanism of curative effect of sinomenine on arthritis concern with rising the level of apoptosis.
[目的]讨采用血液微透析技术研究青藤碱药动学的可行性和优越性。
Objective To explore the feasibility and advantages of blood microdialysis technique for the pharmacokinetic study of sinomenine.
青藤碱的抗类风湿作用可能与其抑制树突状细胞分泌白细胞介素12有关。
The therapeutic effect of sinomenine on rheumatoid arthritis may be related to its inhibition to secretion of IL-12 in DCs.
目的观察中药单体青藤碱对体外培养类风湿关节炎树突状细胞免疫活性的影响。
OBJECTIVE to observe the effect of sinomenine on the immunostimulatory activities of dendritic cells in rheumatoid arthritis in vitro.
结论该方法简便、准确、快速，可用于盐酸青藤碱缓释微丸的含量测定及质量控制。
Conclusion This method is simple, rapid and accurate, which is suitable for the quality control of sinomenine hydrochloride sustained-release pellets.
目的探讨青藤碱(SIN)对大鼠肾移植术后急性排斥反应免疫抑制作用的分子机制。
Objectives To evaluate the effects of the alkaloid sinomenine (sin) on t cell proliferation and acute rejection in rat renal allografts.
目的探讨青藤碱(SIN)对大鼠肾移植术后急性排斥反应免疫抑制作用的分子机制。
Objective To explore the molecular mechanism of immunosuppressive efficacy of alkaloid Sinomenine (SIN) against acute rejection following renal transplantation in rats.
目的：对青藤碱贴剂的透皮吸收数据进行灰色GM(1,1)模型拟合并与相关模型进行比较。
AIM: the transdermal absorption data of sinomenine patch was fitted by grey model GM (1, 1) and compared with other models.
结果：在催促戒断试验中，受试的大、小鼠连续注射青藤碱10天后经纳洛酮催促，均未出现戒断症状及体重下降现象。
Results: in the naloxone-precipitated tests, after injecting sinomenine for 10 days continuously, the mice and rats didn't show any withdrawal symptom and the loss of body weight.
结果：在催促戒断试验中，受试的大、小鼠连续注射青藤碱10天后经纳洛酮催促，均未出现戒断症状及体重下降现象。
Results: in the naloxone-precipitated tests, after injecting sinomenine for 10 days continuously, the mice and rats didn't show any withdrawal symptom and the loss of body weight.
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