目的合成盐酸托烷司琼并改进其合成工艺。
OBJECTIVE To synthesize Tropisetron hydrochloride and optimize the process.
但完全控制率托烷司琼优于昂丹司琼（P<0.05）。
Tropisetron was superior to ondansetron in the complete control rate(P<0.05).
以淀粉为主要填充剂，采用不同工艺制备盐酸托烷司琼胶囊。
The tropisetron hydrochloride capsules were prepared by different methods with starch as main excipient.
结论盐酸托烷司琼氯化钠注射液治疗化疗药物所致恶心、呕吐安全有效。
Conclusion Tropisetron hydrochloride and sodium chloride injection is safe and effective on nausea and vomiting induced by chemotherapy.
目的：系统评价托烷司琼预防全麻术后恶心呕吐(PONV)的有效性。
Objective: to systematically evaluate the efficacy of tropisetron for postoperative nausea and vomiting (PONV).
所述的止吐药剂为格拉司琼、昂丹司琼、托烷司琼、阿瑞匹坦或甲氧氯普胺。
The compound preparation is prepared from the rolipram and the granisetron, the ondansetron, the tropisetron, the aprepitant or the metoclopramide.
结果：托烷司琼组与恩丹西酮组止吐疗效比较有显著性差异（P<0.05）。
Results:The effective rate of Tropisetron group was significantly higher than that of the Ondansetron group (P<0.05).
目的：研究国产盐酸托烷司琼胶囊与进口注射液口服给药后的人体相对生物利用度。
OBJECTIVE To study the pharmacokinetics and relative bioavailability of tropisetron hydrochloride domestic capsule and imported injection in healthy volunteers.
以3-吲哚甲酸为起始原料，经氯化亚砜酰氯化、与托品醇缩合合成了托烷司琼盐酸盐。
Tropisetron Hydrochloride was synthesized from 1Hindol-3-carboxylic acid by chloride acetylation and condensation with Tropic alcohol.
临床研究部分是采用中药敷脐联合托烷司琼防治含顺铂化疗方案所致呕吐、食欲减退的临床观察。
Objective: To observe the effects of Tropisetron combined with herbs used externally in treatment of emesis and anorexia caused by cisplatin-based chemotherapy.
目的研究盐酸托烷司琼胶囊的人体药动学和相对生物利用度并求证国产盐酸托烷司琼胶囊的生物等效性。
OBJECTIVE to study the pharmacokinetics and relative bioavailability of tropisetron hydrochloride capsules in healthy volunteers and to evaluate the bioequivalence.
方法：以吲哚-3-甲酸为起始原料，酰氯化后与托品醇锂发生缩合反应，再与盐酸成盐制得盐酸托烷司琼。
Methods tropisetron hydrochloride was synthesized from indol-3-yl carboxylic acid by chlorination and condensation with tropic alcohol lithium, then salt formation with hydrochlororic acid.
采用毛细管气相色谱法，以外标法测定枸橼酸托烷司琼中乙醇、二氯甲烷、氯仿、四氢呋喃、二烷、吡啶和甲苯的含量，用串联的HP -1 0。
A simple capillary GC method for the determination of residual ethanol, dichloromethane, chloroform, tetrahydrofuran, 1, 4 dioxane, pyridine and toluene in tropisetron citrate was established.
采用毛细管气相色谱法，以外标法测定枸橼酸托烷司琼中乙醇、二氯甲烷、氯仿、四氢呋喃、二烷、吡啶和甲苯的含量，用串联的HP -1 0。
A simple capillary GC method for the determination of residual ethanol, dichloromethane, chloroform, tetrahydrofuran, 1, 4 dioxane, pyridine and toluene in tropisetron citrate was established.
应用推荐