低剂量塞来昔布是临床治疗的较好选择。
Low doses of celecoxib is a better choice for the clinical treatment.
塞来昔布具有明显的抑制裸鼠肝转移瘤生长的作用。
Celecoxib could inhibit the growth of the hepatic metastatic tumor obviously.
目的：研究塞来昔布联合热疗对人胰腺癌细胞周期的影响。
Aims: To study the effect of celecoxib combined with thermotherapy on cell cycle of human pancreatic carcinoma.
目的：研究塞来昔布联合热疗对人胰腺癌细胞周期的影响。
Objective To study the inhibiting effects of celecoxib on mice bladder cancer and investigate the mechanism.
因此，我们推测通过联合塞来昔布可以降低化疗药耐受现象的发生。
Therefore, we believe that celecoxib can be combined with other anticancer drugs to reduce drug resistance caused by interleukin-6 STAT3 signals.
然而，由于心血管系统安全问题开始出现，受试者被迫停止服用塞来昔布。
However, subjects had to discontinue taking the drug as concerns about cardiovascular safety began to emerge.
研究者发现，塞来昔布通过降低STAT 3磷酸化，使肝癌细胞走向自毁。
The researchers found that celecoxib decreased STAT3 phosphorylation to cause the liver cancer cells to self-destruct.
目的：探讨选择性环氧舍酶-2抑制剂塞来昔布对大鼠胃肿瘤发生的预防作用。
OBJECTIVE: to investigate the preventive effect of celecoxib, a selective cyclooxygenase (cox) - 2 inhibitor, on stomach tumor in rats.
同时，他们还发现，塞来昔布阻断外源性白介素诱导的STAT 3磷酸化及核转位。
They also found that celecoxib blocked exogenous interleukin-6-induced STAT3 phosphorylation and nuclear translocation.
不同浓度塞来昔布作用HEC-1B细胞24h后，流式细胞仪检测细胞周期和凋亡；
When HEC-1B cells were treated with different concentrations of celecoxib for 24 h, cell cycle and apoptosis were detected by flow cytometry.
目的研究塞来昔布对糖尿病大鼠视网膜血管内皮生长因子表达及视网膜超微结构的影响。
Objective To investigate the effect of celecoxib on vascular endothelial growth factors and ultrastructure in diabetic rats.
组给予塞来昔布胶囊口服，疗程3周，联合玻璃酸钠注射液膝关节腔内注射，疗程5周。
Patients in group B first took celecoxib capsules for 3 weeks, and were given sodium hyaluronate injection into their knees for 5 weeks in combination, with a total treatment course of 5 weeks.
含塞来昔布药物目前在欧盟被批准用于骨性关节炎、类风湿性关节炎和强直性脊柱炎症状的治疗。
Celecoxib-containing products are currently authorised in the European Union for the treatment of the symptoms of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.
目的探讨塞来昔布对实验性结肠癌原位移植瘤生长及环氧化酶- 2 (COX - 2)表达的影响。
Objective to investigate the effect of celecoxib on the cyclooxygenase-2 (COX-2) expression and the growth of orthotopic transplantation tumor in the case of experimental colorectal cancer.
结论塞来昔布可能通过抑制环氧化酶2活性，减少前列腺素e2在大脑皮质中聚集，而抑制VEGF的表达。
Conclusion Celecoxib may reduce the accumulation of prostaglandin E2 by inhibiting cyclooxygenase-2 activity, and thus inhibiting the expression of VEGF.
结论体外塞来昔布抑制HT - 2 9细胞增殖，并诱导细胞凋亡。这种作用可能与阻止细胞周期进展有关。
Conclusions Celecoxib inhibited proliferation and induced apoptosis of human colorectal cancer cell line HT-29, which may be related to blocking the cell cycle progress of HT-29 cells.
联合应用靶向因子如egfr阻滞剂-如厄罗替尼布和环氧化酶2抑制因子(塞来考昔)-还需要临床验证。
Also the combination of different target agents, such as combining the EGFR blockers - such as erlotinib and the cyclooxygenase-2 inhibitor (celecoxib) - needs to be investigated in clinical trials.
联合应用靶向因子如egfr阻滞剂-如厄罗替尼布和环氧化酶2抑制因子(塞来考昔)-还需要临床验证。
Also the combination of different target agents, such as combining the EGFR blockers - such as erlotinib and the cyclooxygenase-2 inhibitor (celecoxib) - needs to be investigated in clinical trials.
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