MGMT和TP53基因在保持基因组稳定性和防止细胞突变或癌变方面具有重要的功能。
MGMT and TP53 genes play an important role in maintaining genomic stability and protecting cells against mutations or carcinogenesis.
以酵母为模式生物，利用表观遗传，分子遗传和生物化学等手段，研究表观遗传调控在维持基因组稳定性中的作用。
Using yeast as model organism, study the contribution of epigenetic regulation to the maintenance of genomic stability, by epigenetic, molecular genetic and biochemic approaches.
在这些基因组稳定性控制发生改变的肿瘤中，化疗诱导的基因改变的累积可能会导致细胞死亡和解释对化疗产生完全反应。
In these tumours with an altered control of genomic stability, accumulation of chemotherapy-induced genetic alterations may contribute to cell death and account for complete response.
Ph 1使小麦的基因组的稳定性增加，但是如果想要更容易配组新基因就要打乱该染色体。
Ph1 gives wheat's genome its stability but has to be switched off to make it easier to slot in new genes.
乳腺癌易感基因，BRCA1，编码一种E3泛素连接酶，BRCA1通过调控DNA损伤反应和DNA修复维持基因组的稳定性。
The breast cancer susceptibility gene, BRCA1, codes for an E3 ubiquitin ligase that functions in the maintenance of genome stability through regulation of the DNA damage response and DNA repair.
染色体末端的端粒对于细胞基因组的遗传稳定性至关重要。
The ends of chromosomes, the telomers, are important for the genetic stability of our cells.
乳腺癌易感基因，BRCA1，编码一种E3泛素连接酶，BRCA1通过调控DNA损伤反应和DNA修复维持基因组的稳定性。
The breast cancer susceptibility gene, BRCA1, codes for an E3 ubiquitin ligase that functions in the maintenance of genome stability through regulation of DNA damage response and DNA repair.
DNA错配修复系统可以识别并纠正DNA复制过程中出现的错误，保证基因组的稳定性和完整性。
DNA mismatch repair system could recognize and repair mistakes in process of DNA replication, guard stability and integrality of genome.
结论黑色素瘤的发生可能与基因组不稳定性有关。
Conclusion The occurrence of melanoma might be associated with genetic genomic instability.
砷可能通过抑制砷中毒患者皮肤组织中MGMT、XRCC1等DNA修复基因的表达，影响基因组d NA稳定性和DNA修复功能而导致对皮肤的致癌作用。
Arsenic causes carcinogenicity on human skin through inhibiting the expressions of MGMT, XRCC1 and influencing the genetic stability and the DNA repair function.
依托泊苷能稳定酶催化性循环中的一种共价的拓扑异构酶ii裂解的DNA中间复合物，导致基因组不稳定性和细胞死亡(2,3)。
Etoposide stabilizes a covalent topoisomerase II-cleaved DNA intermediate complex in the catalytic cycle of the enzyme, leading to genomic instability and cell death (2, 3).
真核生物对维持基因组的稳定性及防止非整倍体的产生，有其一套完整的保护机制，即细胞周期调控、检验点调控以及对损伤DNA的修复。
To ensure genome integrity and prevent aneuploidy, eukaryotes have evolved an integrated protective mechanism, including cell cycle control, checkpoint control, and DNA repair.
有很多原因可以解释，包括：乏氧驱使基因组不稳定性及改变DNA损伤修复通路的能力。
There are several reasons why this might be, including the capacity of hypoxia to drive genomic instability and alter DNA damage repair pathways.
DNA损伤反应机制的任何功能缺陷将会引起基因组的不稳定性，从而导致癌症的发生。
Defects in DNA damage response can cause genome instability, which induces many human cancers.
DNA损伤反应机制的任何功能缺陷将会引起基因组的不稳定性，从而导致癌症的发生。
Defects in DNA damage response can cause genome instability, which induces many human cancers.
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