结论黑色素瘤的发生可能与基因组不稳定性有关。
Conclusion The occurrence of melanoma might be associated with genetic genomic instability.
有很多原因可以解释，包括：乏氧驱使基因组不稳定性及改变DNA损伤修复通路的能力。
There are several reasons why this might be, including the capacity of hypoxia to drive genomic instability and alter DNA damage repair pathways.
依托泊苷能稳定酶催化性循环中的一种共价的拓扑异构酶ii裂解的DNA中间复合物，导致基因组不稳定性和细胞死亡(2,3)。
Etoposide stabilizes a covalent topoisomerase II-cleaved DNA intermediate complex in the catalytic cycle of the enzyme, leading to genomic instability and cell death (2, 3).
DNA损伤反应机制的任何功能缺陷将会引起基因组的不稳定性，从而导致癌症的发生。
Defects in DNA damage response can cause genome instability, which induces many human cancers.
DNA损伤反应机制的任何功能缺陷将会引起基因组的不稳定性，从而导致癌症的发生。
Defects in DNA damage response can cause genome instability, which induces many human cancers.
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