目的：为了促进药物代谢酶在临床上的深入研究。
Objective: To promote the study of drug metabolic enzymes in clinical practice.
致癌物代谢酶基因多态是肿瘤遗传易感性的一个重要方面。
Genetic polymorphism of carcinogen metabolizing enzymes is one of the important aspects of the genetic susceptibility to cancer.
肿瘤易感性与异源物代谢酶遗传多态性和染色体畸变等相关。
Tumour susceptibility is associated with genetic polymorphism of xenobiotics metabolism enzyme and chromosomal aberrations et al.
目的：综述近年来中药有效成分对药物代谢酶的影响的研究进展。
Objective: To review the effects of the active components of Chinese herbs on drug metabolizing enzymes.
分子伴侣能解救构象性疾病，使晶状体重要的代谢酶‘起死回生’。
Molecular chaperone may rescue the conformational diseases and revive the inactive enzymes in lens.
冻融使VX 非氧化代谢酶活性丧失，但不影响对氧磷水解酶的活性。
These results indicate that the anaerobic VX-metabolizing enzyme is different from soman and paraoxon hydrolases.
目的观察粗叶悬钩子粗多糖对模型大鼠急性肝损伤药物代谢酶的影响。
Objective To investigate the effect of polysaccharide of Rubus alceaefolius Poir on drug-metabolizing enzyme in acute liver injury rats.
提示升高脂类代谢酶的活性可能是理脾化痰降脂片调脂的作用机理之一。
It is suggested that the enhancement of activity of lipid metabolic enzyme may be one of the lipid_reducing mechanisms of LHJT.
结论：药物代谢酶的认识和研究有助于临床合理用药和减少药物不良反应。
Conclusion: the study of drug metabolic enzymes will help to provide safe, rational and effective prescriptions and to decrease the adverse drug reactions.
目的探讨氯乙烯（VCM）所致DNA损伤与VCM代谢酶多态间的关系。
ObjectiveTo explore the relationship between DNA damage induced by vinyl chloride monomer(VCM) and polymorphisms of metabolizing enzymes of VCM.
肠道转运体、肝脏药物代谢酶及肾脏在药物adme过程中发挥着重要作用。
Intestinal drug transporters, hepatic drug metabolic enzymes and the kidney play a very important role in the process of ADME.
在代谢酶方面的变异对酶的活性有很大影响，这些发现目前对我们都很有用。
There are variants in metabolizing enzymes that have significant effects on the activity of those enzymes and they are useful to us right now.
目的研究环境暴露因素与毒物代谢酶基因多态性对发生慢性苯中毒危险性的影响。
Objective to explore the effects of interaction between environmental exposure factors and genetic polymorphism in toxicant metabolizing enzymes on risk of occupational chronic benzene poisoning.
方法：综述近几年具遗传多态性代谢酶的探针药物、代谢分型方法以及影响因素。
METHOD:The probe drugs of drug metabolism, methods of phenotype and related factors were reviewed.
糖类分解代谢酶基因作为安全标记基因，近年来在植物转化中显示了巨大应用潜力。
The genes coding enzymes that catalyze special sugars have showed big practical potency in plant transformation as safe marker genes.
结果提示镉、铅、汞可能通过降低微粒体酶的新生合成，抑制肝微粒体药物代谢酶。
The results suggested that the inhibition of hepatic microsomal drug-metabolizing enzymes by cadmium, lead or mercury was produced by decreased neosynthesis of microsomal enzymes.
介绍苯致血液毒性两大类主要的易感性标记物、代谢酶，DNA修复酶及其多态性；
This review is focused on two main types of markers of susceptibility to benzene-induced hematotoxicology, metabolizing enzymes, DNA repairing enzymes, their polymorphisms are also addressed.
本文比较了普通甜瓜变种和越瓜变种果实发育过程中糖分转化与有关代谢酶活性变化。
Sugar contents and its related metabolic enzyme activities were compared in developing fruits of C. melo.
结论本研究表明，乳腺癌细胞中，不同类型的孕激素对雌激素代谢酶具有不同的作用。
Conclusions: The present study suggested that different type of progestins exerts different actions on sulfates and sulfotransferase in breast cancer cells.
嫁接伽师瓜间果实发育过程中蔗糖、葡萄糖、果糖和糖代谢酶活性变化趋势基本一致。
The transition of sugar accumulation and activity of sucrose-metabolizing enzymes during fruit development of grafted and non-grafted muskmelon were similar.
通过比较，发现凝胶包埋细胞比单层贴壁培养细胞能更好地保持各项药物代谢酶的活性。
By comparison of enzyme activitys in gel entrapment and monolayer culture, it was concluded that cells of gel entrapment can maintain these enzyme activity better than those of monolayer.
有机酸相关代谢酶的活性表现为：柠檬酸合酶（CS）活性变化与有机酸含量相关性不大；
The activities of organic acids-metaboling enzymes showed: There was no relation between the activity of citrate synthase(CS) and organic acids concentration.
它们具有多种生物学功能，既能作为代谢酶也可作为结合蛋白在多种解毒过程中发挥作用。
They are mulifunctional proteins that act as enzymes and also as binding proteins in various detoxification processes.
根据动物实验来预测人体的药物代谢时，代谢酶的种属差异性会使这项研究工作变得非常困难。
Predicting of drug metabolism in humans based on animal experiments is complicated by species differences in the catalytic properties of these enzymes.
结论VLBW出生时已有骨代谢酶的异常，动态监测alp的变化可早期发现VLBW骨代谢病。
Conclusions VLBW has abnormal bone metabolism at birth, monitoring serum ALP level change can detect early bone metabolism abnormality.
差异表达的基因的功能涉及细胞生长增殖调控、凋亡、细胞周期、应激反应、转运及代谢酶等方面。
The expressions of the various genes modulated cell growth and proliferation, apoptosis, cell cycle, stress response, transporters, chaperones, transcription regulation and drug metabolism.
药物代谢酶、转运体及药物作用靶点存在着的基因多态性与药物疗效和毒性的个体差异有很大关系。
The genetic polymorphism of drug metabolizing enzyme, transporter and target greatly influence the individual difference of drug efficiency and toxicity.
氧化苦参碱是自中药苦参中提取的一种生物碱，本文就其对小鼠肝微粒体药物代谢酶的影响进行了探讨。
The effect of Oxymatrine(OMT), isolated from Sophora flavescens Ait, on the hepatic microsomal drug-metabolism enzyme have been investigated.
目的本研究旨在观察沙坦类药物代谢酶CYP2C9和反应受体AT1的遗传多态性在高血压患者中的分布特征。
Objective To investigate the genetic polymorphism of sartan drug metabolic enzyme CYP2C9 and angiotensin AT1 receptor in hypertensive patients.
目的本研究旨在观察沙坦类药物代谢酶CYP2C9和反应受体AT1的遗传多态性在高血压患者中的分布特征。
Objective To investigate the genetic polymorphism of sartan drug metabolic enzyme CYP2C9 and angiotensin AT1 receptor in hypertensive patients.
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