Objective: To study the expression of MUC1 and WT1 gene in acute leukemia and their clinical significance.
目的：探讨MUC1基因及WT 1基因在急性白血病的表达及临床意义。
Objective:To explore the expression and significance of the WT1 gene and proteins in patients with acute myelocytic leukemia(AML).
目的：探讨WT1基因及其蛋白产物在急性髓细胞白血病（AML）细胞的表达及临床意义。
Conclusion Monitoring of the WT1 gene by Nest RTPCR would be a surely marker for the detection of minimal residual disease (MRD) in acute leukemia.
结论用Nest、RT - PCR测定WT 1基因的表达可作为检测白血病微小残留病(MRD)的一项指标。
Method The expression of WT1 gene and its DNA methylation status were assayed in leukemia cell lines and normal peripheral blood mononuclear cells (PBMNC) by RT-PCR and MS-PCR.
方法采用RT P CR技术、硫化pcr结合限制性内切酶技术检测白血病细胞系及正常人外周血单个核细胞WT 1基因的表达及其启动子区DNA甲基化水平。
None was WT1 positive in peripheral blood mononuclear cells (MNC) from 29 blood donors, while bone marrow MNCs from eight of 21 cases (38.1%) of nonmalignant patient WT1 gene expression were found.
在2 9例供血员的外周血单个核细胞（MNC）均未检测到WT1基因表达，但在2 1例非恶性疾病患者骨髓MNC中有8例呈WT1基因阳性（38.1% ）。
Objective: To elucidate the expression of Wilms' tumor gene (WT1) in leukemias and its clinical implication.
目的：探讨WT 1基因在白血病细胞中的表达及其临床意义。
Objective To analyze mutations in the Wilms tumor gene (WT1) in Ieukemogenesis.
目的瘤基因(WT1)突变与白血病发病的关系。
Objective To analyze mutations in the Wilms tumor gene (WT1) in Ieukemogenesis.
目的瘤基因(WT1)突变与白血病发病的关系。
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