WIP1 was initially identified as a p53 target gene, induced in response to ionizing radiation (1).
WIP1最初被认为是电离辐射应激后p 53的靶基因(1)。
Researchers have shown that increased expression of WIP1 is associated with poor prognosis and lower survival rate in some human cancers (7, 8).
研究人员发现WIP1的过表达与某些人类肿瘤的不良预后和低存活率相关(7,8)。
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly240 of human WIP1 protein.
单克隆抗体由合成肽段免疫动物产生，该肽段与人WIP1蛋白的240位甘氨酸邻近残基序列一致。
Studies have shown that WIP1 is overexpressed in human cancers and is involved in the regulation of multiple DNA damage signaling pathways (reviewed in 2,3).
研究证明WIP1在人类癌症中过表达并设计到调控多种DNA损伤信号通路（2，3）。
WIP1 functions in returning cells to a homeostatic state following DNA damage (4,5), as well as in maintaining p53-dependent homeostasis under nonstress conditions (6).
WIP1发挥着在DNA损伤后将细胞送回稳定状态的功能（4，5），同时也维持着非压力条件下p53-依赖的稳态（6）。
WIP1 functions in returning cells to a homeostatic state following DNA damage (4,5), as well as in maintaining p53-dependent homeostasis under nonstress conditions (6).
WIP1发挥着在DNA损伤后将细胞送回稳定状态的功能（4，5），同时也维持着非压力条件下p53-依赖的稳态（6）。
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