The aim of the paper is to provide helpful Suggestions for the formula design and development of microspheres loaded with small molecular and water soluble drugs.
探讨微球制剂的载药、释药机制，为处方设计和水溶性小分子药物微球制剂的开发提供指导。
The bioactivity of GLP-1 was conserved with glutin as inner water phase, but in the course of in vitro release, the specific activity of GLP-1 in the microspheres decreased a little.
使用明胶溶液作为内水相，较好地保持了制备工艺过程中的GLP-1生物学活性，在体外释放过程中GLP-1的生物学活性略有下降；
Compared to microspheres with low water absorbing rate, the high batches had higher drug-loading rate and entrapment rate.
吸水度高的微球载药量和包封率较吸水度低的微球高。
According to the present invention, the desired polymeric microspheres loaded with drugs can be simply produced with a small amount of water in a short period of time.
按照上述的本发明方法，就可以用少量的水在短时间内简便地制造所需的含药物高分子微球。
The microspheres of PEG-PLA block copolymers can enhance the stability of protein and polypeptide, and profit the release of poorly water-soluble pharmaceuticals.
该嵌段共聚物微球能提高蛋白、多肽的稳定性，有利于难溶性药物释放。
The microspheres of PEG-PLA block copolymers can enhance the stability of protein and polypeptide, and profit the release of poorly water-soluble pharmaceuticals.
该嵌段共聚物微球能提高蛋白、多肽的稳定性，有利于难溶性药物释放。
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