Objective To use ANN to quantitatively predict the influence of the amount of HPMC and its internal viscosity on allopurinol release from HPMC sustained release tablets.
目的用人工神经网络模型定量的预测HPMC的量和其固有黏度对药物释放的影响。
Conclusion: the amount and viscosity of HPMC significantly influence aspirin release from the gastric floating capsule.
结论H PM C用量、粘度为影响阿司匹林胃漂浮胶囊释放速率的主要因素。
If the capsule's quality can't meet the demand, the excessive rapid release speed of the breaker would lead to the fracture fluid viscosity premature descending and inducing the failure of work.
但是如果制作胶囊破胶剂的囊壳材料不好，胶囊破胶剂释放速率过快则会使压裂液提前破胶，导致施工失败。
CONCLUSION: the amount, particle size and viscosity of HPMC, preparation method, tablet size as well as the additives significantly influenced aspirin release from HPMC matrix tablet.
结论：HPMC用量、粘度和粒度、制片方法、片剂大小及其它辅料为影响阿司匹林骨架片释放速率的主要因素。
The results showed that the lag time before drug release was lengthened with the increase of the viscosity grade of HPMC.
结果表明，HPMC粘度增加使药物释放滞后时间延长，但高粘度HPMC会导致药物释放无明显突跃点；
The effects of HPMC viscosity on drug release varied with drug release mechanisms;
②HPMC黏度对骨架释放的影响随骨架释药机制不同而不同；
Conclusions Ibuprofen sustained release tablets with ideal release behavior could be prepared by selecting HPMC with different viscosity and adjusting the content of HPMC.
结论联合应用不同黏度和用量的HPMC，可制备具有理想释药行为的布洛芬骨架缓释片。
METHODS Different particle size of tramadol hydrochloride, viscosity grades and the amount of HPMC, additive content and process were used to prepare tramadol hydrochloride sustained release tablets.
方法分别采用不同黏度与用量的羟丙甲纤维素(HPMC)，不同主药粒径与稀释剂，不同工艺制备盐酸曲马多缓释片。
Low viscosity PC Copolymer blend, enhanced UV stabilization, mold release added.
低粘度PC共聚物混合、增强的紫外线稳定、脱模补充道。
Medium viscosity PC Copolymer blend, enhanced UV stabilization, mold release added.
介质粘度PC共聚物混合、增强的紫外线稳定、脱模补充道。
Medium viscosity PC Copolymer blend, enhanced UV stabilization, mold release added.
介质粘度PC共聚物混合、增强的紫外线稳定、脱模补充道。
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