Most patients with isolated hemangioblastomas of the cerebellum do not have VHL.
大多数孤立性血管母细胞瘤并没有VHL疾病。
The mutations of VHL gene were irrespective of the age and pathological grade and stage of patients.
结论：国人非遗传性肾透明细胞癌中存在VHL基因的突变，且与患者年龄，肿瘤分期、分级无相关性。
The VHL gene may be useful as a marker gene for the diagnosis of RCC and as a target gene for molecular therapy.
VHL基因可作为临床诊断指标，并可望成为肾透明细胞癌基因治疗的重要目的基因。
Conclusion The VHL gene may frequently mutate in Chinese patients with primary sporadic renal clear cell carcinoma.
结论国人原发性散发性肾透明细胞癌中存在VHL基因的突变。
Results VHL gene mutation was detected in 10(35.7%) CCRCC tumor samples. There was no mutation detected in all normal kidney tissues.
结果远离肿瘤的正常肾组织中未检测到VHL基因的突变，10例（35·7%）癌组织标本中存在VHL基因的突变。
Only 5%-30% of all cerebellar hemangioblastomas are attributed to VHL disease, whereas 80% of spinal cord hemangioblastomas occur with the disease.
只有5% - 30%的小脑血管母细胞瘤是归因于VHL病，但是80%的脊髓血管母细胞瘤发生在VHL病中。
Objective To investigate the mutation of Von Hippel-Ldau(VHL)tumor suppressor gene in peatients with primary sporadic human renal cell carcinoma(RCC).
目的探讨国人原发性散发性肾透明细胞癌中VHL抑癌基因突变及其意义。
CONCLUSIONS: Review of the literature confirms that cranial nerve hemangioblastomas are very rare lesions that occur sporadically or in association with VHL disease.
结论∶文献回顾证实脑神经成血管细胞瘤是极为罕见的病变，散发或与VHL病并发。
CONCLUSIONS: Review of the literature confirms that cranial nerve hemangioblastomas are very rare lesions that occur sporadically or in association with VHL disease.
结论∶文献回顾证实脑神经成血管细胞瘤是极为罕见的病变，散发或与VHL病并发。
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