Inhibition by co-applied QX-314 and capsaicin was restricted to neurons expressing TRPV1.
联合应用QX-314与辣椒素所产生的抑制作用仅局限在有TRPV1表达的神经元。
But because it binds to the TRPV1 receptor, the brain is tricked into believing that the tongue truly is on fire.
但因为和TRPV 1受体结合，大脑便错误的认为舌头着火了。
Scientists have long known that the nervous system receptor known as TRPV1 can affect sensations of pain in the body.
科学家一直知道神经系统受体如已知的TRPV 1能影响机体的疼痛感觉。
Study on role of TRPV1 and its mechanisms will help us to understand pain physiology and to develop new analgesic drugs.
深入研究TRPV1的作用机制，有助于理解痛觉生理和开发新型镇痛药物。
TRPV1 receptors not only respond to heat but also to capsaicin, the compound that creates the spicy kick in chili peppers.
TRPV 1受体不仅对热起反应也对辣椒碱有反应，成分是由辣椒胡椒辛辣素产出。
Other drugs aimed at reducing pain and inflammation by blocking or activating TRPV1 receptors are in the research pipeline.
其他药物的目的在于通过阻断或激活TRPV 1受体减少疼痛和炎症，这还在研究中。
The team found that this compound activated TRPV1 channels - which alone triggered long-term depression in the brain tissue.
她的团队发现这个成分激活TRPV 1通道，它可以独自激发脑组织的长时程抑郁。
TRPV1 can detect noxious stimulus and convert it into action potentials traveling to the central and forming pain sensation.
TRPV 1能够感受伤害性刺激，将之转化为动作电位，传至中枢形成痛觉。
When scientists discovered that the VR1 receptor was a member of the larger family of TRP ion channels, the VR1 receptor was renamed TRPV1.
科学家们发现VR1受体是瞬时受体电位通道(TRPion channels)家族的一员，于是VR1受体又被命名为TRPV1。
The third chapter was devoted to the study of quantitative structure-activity relationship(QSAR) for indazolyl ureas as TRPV1 antagonists.
第三章致力于吲唑脲类辣椒素受体（TRPV1）通道拮抗剂的定量构效关系（QSAR）研究。
But antipain specificity is ensured by allowing it to enter via the TRPV1 channel, a capsaicin receptor found only in pain-sensing neurons.
但通过允许它经TRPV1通道（一种辣椒素受体）进入细胞可保证其止痛特效，这个通道在细胞中只在痛觉神经元中表达。
Conclusion: XTTL Gel may alleviate bone cancer pain by inhibition of bone resorption and down regulation TRPV1 expression in the bone and hypothalamus.
结论：消痰通络凝胶可有效抑制骨癌痛，其治疗骨癌痛的机理可能与减少骨吸收、下调骨及下丘脑TRPV1的表达有关。
"Our findings suggest the possibility that some of the psychiatric side effects from rimonabant could be due to the blocking of TRPV1 receptors," she said.
“我们的发现提示来自利莫那班的精神副作用的可能性归咎于TRPV 1受体的阻断”她说。
Conclusion TRPV1 transgenic mice have been established successfully. The model will contribute to the further research of the physiological function of TRPV1.
结论成功建立了TRPV 1转基因小鼠模型，为深入研究TRPV1的功能提供了更好的条件。
As detected by Western blotting, TRPV1 expressions in the brain and skeletal muscle of the transgenic mice were significantly higher than the wild-type littermates.
经蛋白免疫印记法证实，与同窝野生型小鼠相比，转基因小鼠的脑组织和肌肉组织中TRPV1的表达显著升高。
Here we show that charged sodium-channel blockers can be targeted into nociceptors by the application of TRPV1 agonists to produce a pain-specific local anaesthesia.
结果显示，应用TRPV 1激动剂能够使带电的钠通道阻断剂特异性地作用于疼痛感受器神经元而产生特异性局麻止痛效果。
Conclusion Vagal primary afferent neurons of the small intestine express at least three types of acid-responsive ion channels, including TRPV1 and two subtypes of ASIC.
结论小肠迷走神经初级传入神经元至少表达三种对酸反应的离子通道，分别是ASIC的两种不同亚型和TRPV1。
When having a hot drink, nerve receptors in your tongue (specifically the TRPV1 receptor) signal to the rest of your body that something "hot" is coming and you need to start sweating.
当喝热饮的时候，你舌头上的神经感受器(尤其是TRPV 1感受器)会向你身体的其他部位发出信号：“热流”来了，你要准备好出汗了。
In inflammatory pain, a number of inflammatory mediators are released, which modulate TRPV1 activity through various signal pathways or interact with TRPV1 generating pain or hyperalgesia.
炎症时释放的许多炎症介质都能够与TRPV 1发生相互作用，产生疼痛或痛觉过敏，并且通过各种不同的信号通路来调制TRPV1的活性。
The team then tested brain tissue from mice that lacked TRPV1 receptors and found that long-term depression was absent - and that applying capsaicin still couldn't elicit the changes to the synapses.
团队后来检验了小鼠的脑组织，它缺乏TRPV1受体并发现长时程抑郁缺失，应用辣椒碱也不能引发突触改变。
The team then tested brain tissue from mice that lacked TRPV1 receptors and found that long-term depression was absent - and that applying capsaicin still couldn't elicit the changes to the synapses.
团队后来检验了小鼠的脑组织，它缺乏TRPV1受体并发现长时程抑郁缺失，应用辣椒碱也不能引发突触改变。
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