His team is now testing drugs that block TLR4.
他的小组现在测试封阻tlr 4药物。
The lack of TLR4 in those cells diminishes these effects.
而TLR4缺乏的细胞，这种效应降低。
TLR4 is expected to become a new target for cancer biotherapy.
TLR4有望成为肿瘤生物治疗的新靶点。
Olefsky concludes that TLR4 mediates the immune system's response to fat.
Olefsky推断TLR4介导免疫系统对脂肪的应答。
TLR4 muscle protein content correlated with the severity of insulin resistance.
肌组织中tlr4蛋白含量与胰岛素抵抗的轻重有联系。
Then they injected the mice with macrophages lacking a surface protein called TLR4.
然后他们用缺乏一种TLR4表面蛋白的巨噬细胞注射小鼠。
However, it is not known whether insulin-resistant subjects have abnormal TLR4 signaling.
然而尚不清楚胰岛素抵抗者是否有不正常的TLR4信号。
Here we will review the most recent progress on TLR4, TLR4 signaling and viral infections.
该文将介绍TLR4的生物学特性、信号转导通路及TLR4与病毒感染的最新研究进展。
And the mice deficient in the TLR4 receptor showed dramatically lower levels of the cytokines.
并且，缺乏TLR4受体的小鼠，其细胞因子水平明显降低。
The discovery of TLR4 has greatly promoted understanding on the LPS signal transduction pathway.
TLR4的发现使我们对LPS信号转导通路的认识前进了一大步。
In recent years, TLR4 as a transmembrane receptor has concernd with respiratory system diseases.
近年来的众多研究表明，TLR4作为跨膜受体与呼吸系统的多种疾病有着密切的联系。
Objective To investigate the expression of TLR2 and TLR4 in human peripheral blood monocyte after burn.
目的观察烧伤患者外周血单个核细胞表面tlr2、TLR4表达的变化。
Conclusions:There were stronger expressions of TLR4 in the heavier adenoid hypertrophy and in combined with OME.
结论：合并分泌性中耳炎和增殖程度较重的腺样体组织中TLR4表达增强；
Conclusion TLR2 and TLR4 may have a role in the pathogenesis of chronic hepatitis B and chronic severe hepatitis B.
结论TLR2和TLR4可能与慢性乙型肝炎及慢性重型乙型肝炎的发病有关。
The aim of this study was to investigate the distribution of TLR4 polymorphisms in the general population of China.
本研究将建立中国汉族正常人群TLR4基因座位的单核苷酸多态性图谱。
RESULTS— Obese and type 2 diabetic subjects had significantly elevated TLR4 gene expression and protein content in muscle.
结果—肥胖者和2型糖尿病患者在肌肉组织中TLR4基因的表达和其蛋白含量显著增加。
Toll-like receptor 4(TLR4) recognizes pathogen ligands and mediates signaling to initiate innate and adaptive immune responses.
TLR4通过识别病原体而激活免疫细胞，在先天免疫和适应性免疫防御中起着重要作用。
TLR4 expression in gastric mucosa with intestinal metaplasia, dysplasia is significantly higher than that in gastric cancer mucosa.
肠化、不典型增生胃粘膜组织tlr4的阳性表达明显高于胃癌组织。
We examined whether insulin-resistant subjects have abnormal TLR4 expression and TLR4-driven ( IkB/NFkB ) signaling in skeletal muscle.
我们验证胰岛素抵抗者在骨骼肌中是否有的TLR4异常表达和TLR4促进信号（IkB/NFkB ）。
The inhibition effectiveness on LPS-TLR4 complex internalization was examined by flow cytometry and confocal laser scanning microscopy;
应用LPS刺激内化障碍巨噬细胞，流式细胞仪、激光共聚焦显微镜检测LPS-TLR4复合物内化抑制情况；
Study of TLR4 can further understand the pathogenesis of respiratory diseases in order to find a better anti-infective, anti-inflammatory treatment.
对TLR4的研究可以进一步了解呼吸系统疾病的发病机制，以寻找更好的抗感染、抗炎症的治疗方法。
Conclusion That TLR2 and TLR4 both expressed in human urinary tract epithelium is probably associated with the distribution of uropathogenic bacteria.
结论人尿路上皮细胞中TLR2和TLR4均有表达，尿路感染致病菌分布量可能与TLR亚型表达情况有关。
TLR4 is a newly found transmembrane receptor of LPS, which is responsible for LPS-induced inflammatory cytokines production of inflammatory cytokines.
TLR4是近年新发现的LPS受体，在LPS的胞内信号转导过程中起重要作用。
Conclusion: TLR4 over expressed in breast cancer can promote cell proliferation, and play an important role in the pathogenesis of human breast cancer.
结论：乳腺癌组织tlr4高表达，促进癌细胞的增殖，在乳腺癌的形成过程中起到了重要的作用。
In this review, we summarize the function and signal transduction pathways of TLR4 and the correlation between genetic polymorphism of TLR4 and sepsis.
现就TLR4的功能、信号转导通路及其基因多态性与脓毒症易感性的相关关系作一综述。
Ethanol molecules suppress TLR4's usual ability to send signals that would normally trigger the production of inflammatory cytokines, the authors suggest.
作者提出，酒精分子抑制了TLR4的保护炎症细胞因子的能力。
Objective It is to discuss the influence of total saponins panax notoginseng (PNS) on CD14 and TLR4 of mononuclear cell in acute cerebral infarct patients.
目的探讨三七总皂苷(PNS)对急性脑梗死患者单核细胞CD 14及TLR4的影响。
The increase in TLR4 and NFB signaling was accompanied by elevated expression of the NFB-regulated genes interleukin (IL)-6 and superoxide dismutase (SOD)2.
TLR4和NFB信号的增加伴随着NFB调节的白介素-6（IL-6）和超氧化剂歧化酶2 （SOD2）基因的表达升高。
Methods Expression of TLR2 and TLR4 was measured in 16 specimens from lesions of guttate psoriasis, 13 from chronic plaque psoriasis and 10 from normal skin.
方法选用16例滴状银屑病、13例斑块状银屑病患者及10例正常人皮肤的石蜡切片，用免疫组化的方法研究TLR2和TLR4的表达。
Methods Expression of TLR2 and TLR4 was measured in 16 specimens from lesions of guttate psoriasis, 13 from chronic plaque psoriasis and 10 from normal skin.
方法选用16例滴状银屑病、13例斑块状银屑病患者及10例正常人皮肤的石蜡切片，用免疫组化的方法研究TLR2和TLR4的表达。
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