Objective: To illustrate the effect on myeloma cells with TK gene by GCV.
目的：探讨更昔洛韦对转染TK基因的骨髓瘤细胞生长的抑制作用。
The study demonstrated that L5178Y TK gene mutation assay ism ore sensitive than micronucleus and comet assay.
与微核试验和彗星试验比较证实，L 5 178y细胞TK基因试验检测基因突变更加灵敏。
Methods a retroviral vector containing TK gene was constructed and transduced into pulmonary adenocarcinoma cell A549 by electroporation.
方法构建含tK基因的逆转录病毒表达载体，电穿孔法转化肺癌细胞A549。
Objective To establish TK gene mutation assay using human lymphoblastoid cell line TK6 and to study the genotoxic mechanism of Vinblastine(VBL).
目的建立用人类淋巴母细胞TK 6检测纺锤体毒物——长春花碱的TK基因突变试验方法，同时探讨长春花碱的遗传毒性分子机理。
The basic elements of Duck Plague Virus TK gene and physicochemical properties, structure, function of TK protein were analyzed by using bioinformatics method.
运用生物信息学方法，对鸭瘟病毒TK基因的基本元件和TK蛋白的理化性质、结构、功能进行分析。
This paper introduce the differences in thymidine kinase (tk) isoenzymes and the relation of them to cancer and cell cycle as well as the progress of gene-therapy of cancer based on tk gene.
重点介绍了各种胸苷激酶(tk)同工酶的差异及其与癌症和细胞周期的关系，并介绍了最近利用tk基因进行肿瘤基因治疗研究的进展。
Objective: to study Somatic mutation of the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR gene) in lung adenocarcinoma patients.
目的：探讨表皮生长因子受体(EGFR)基因酪氨酸激酶域体细胞在肺腺癌患者中突变的相关因素。
Conclusion HSV-TK/GCV gene therapy system may provide a new therapeutic approach for treatment of osteosarcoma.
结论HSV-TK/GCV基因治疗系统可为骨肉瘤的治疗提供新途径。
TK6 cells can be used as an in vitro assay system to assess cytogenetic damage and gene mutation at tk locus of environmental chemicals.
TK 6细胞可用于评估环境化学物细胞水平遗传改变及TK基因突变。
The following work were done in this study: (1)TK and P32 gene of GTPV-TY were cloned by PCR with primer pairs designed by information published on GENBANK;
主要进行了以下工作：（1）根据GENBANK公布的羊痘病毒基因组序列设计引物，利用PCR克隆GTPV-TY株TK基因和P32基因；
TK contained ALBTRS promoter sequence which probably control the targeting expression in hepatocyte of target gene TK. The enzyme cut assay of the vector LN. ALBTRS.
TK的结构中，含有ALBTRS启动子，具有在表达白蛋白的肝细胞中特异表达的潜能，载体经酶切鉴定表明结构符合要求。
The use of negative selection gene (HSV-tk) results in 7-fold increase at selection efficiency.
负向选择系统的应用使同源重组事件的富集效率提高了7倍。
The use of negative selection gene (HSV-tk) results in 7-fold increase at selection efficiency.
负向选择系统的应用使同源重组事件的富集效率提高了7倍。
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