OBJECTIVE To prepare thymopentin microspheres and investigate the drug release in vitro.
目的制备胸腺五肽微球并对其体外释放进行考察。
Methods Using HPLC method, we investigated the influence of different temperature, sonification time and pH value on thymopentin.
方法采用高效液相色谱法(HPL C)，研究胸腺五肽在不同温度、超声时间及p H值条件下的稳定性。
The results show that the major component of the crude peptide is the target peptide thymopentin and the main by-products are derived from incomplete deprotection of the desired peptide.
结果证明，粗产物中的主成分即为目标五肽，另外几个主要副产物为五肽合成过程中去保护未完全的副产物。
Conclusions There are some surely therapeutic effect for cisplatin combination with thymopentin on patients with malignant pleural effusion, and it can improve their quality of life (QOL).
结论顺铂联合胸 腺 五肽治疗恶性 胸腔积液有确切疗效，明显提高化疗药物敏感性，进而提高患者的生活质量。
Conclusions There are some surely therapeutic effect for cisplatin combination with thymopentin on patients with malignant pleural effusion, and it can improve their quality of life (QOL).
结论顺铂联合胸 腺 五肽治疗恶性 胸腔积液有确切疗效，明显提高化疗药物敏感性，进而提高患者的生活质量。
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