Although many proto-oncogenes and tumor suppressor genes are widely expressed, the mutation of these genes is associated with cancer of specific organs or cell types.
虽然许多原癌基因和肿瘤抑制基因被广泛表达，这些基因的突变与特定的器官或细胞类型的癌有关。
The different mechanisms, such as the activation of oncogenes, the inactivation and mutation of tumor suppressor gene, antiapoptosis and so on are involved in .
原癌基因的激活，抑癌基因的失活、突变，抗细胞凋亡等不同的机制都可能参与其中。
Pathology: p53 tumor suppressor gene mutation, loss of heterozygosity (LOH) at 11p15 locus. PAX-FKHR gene fusion.
病理学：p53肿瘤抑制基因突变，第11p15基因座杂和性丢失。
Expression of the PTEN tumor suppressor is frequently lost in breast cancer in the absence of mutation or promoter methylation through as yet undetermined mechanisms.
PTEN肿瘤抑制因子在乳腺癌中虽常呈失表达，但并不是通过基因突变或促进子甲基化而实现的，因此其失表达的机制还不清楚。
Objective: To investigate the mutation of RB tumor suppressor gene in Wilms tumor and to explore the relationship between RB mutation and the pathogenesis of Wilms tumor.
目的：调查肾母细胞瘤中RB基因突变，探讨RB基因突变与肾母细胞瘤发生的关系。
Objective To investigate the mutation of Von Hippel-Ldau(VHL)tumor suppressor gene in peatients with primary sporadic human renal cell carcinoma(RCC).
目的探讨国人原发性散发性肾透明细胞癌中VHL抑癌基因突变及其意义。
Objective To investigate the mutation of Von Hippel-Ldau(VHL)tumor suppressor gene in peatients with primary sporadic human renal cell carcinoma(RCC).
目的探讨国人原发性散发性肾透明细胞癌中VHL抑癌基因突变及其意义。
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