Conclusion SLPI can inhibit LPS-induced inflammation in lung of newborn rats.
结论SLPI对LPS致新生大鼠急性肺损伤有抗感染作用。
Objective To investigate the anti-inflammatory effects of secretory leukocyte protease inhibitor(SLPI) on newborn rats with lipopolysaccharide(LPS)-induced acute lung injury(ALI).
目的探讨分泌型白细胞蛋白酶抑制剂（SLPI）对内毒素（LPS）致新生大鼠急性肺损伤（ALI）的抗感染作用。
SLPI possesses potent inhibitory activity against neutrophil elastase, cathepsin g, chymase, trypsin and chymotrypsin and play an important role in allergic and inflammatory diseases.
SLPI能抑制中性粒细胞的弹性蛋白酶、组织蛋白酶g、肥大细胞的类糜蛋白酶、胰蛋白酶和糜蛋白酶，在变态反应性疾病和炎症中起重要作用。
SLPI possesses potent inhibitory activity against neutrophil elastase, cathepsin g, chymase, trypsin and chymotrypsin and play an important role in allergic and inflammatory diseases.
SLPI能抑制中性粒细胞的弹性蛋白酶、组织蛋白酶g、肥大细胞的类糜蛋白酶、胰蛋白酶和糜蛋白酶，在变态反应性疾病和炎症中起重要作用。
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