Can the HMGB1-CD24-Siglec system limit the more severe forms of sterile inflammation, such as sepsis?
HMGB1 -CD 24 -Siglec系统能限制更严重的无菌性炎症反应，如脓毒症吗？
In fact, HMGB1 was found to directly associate with CD24 and Siglec-G, a member of the sialic acid-binding immunoglobulin-like lectin family.
实际上，HMGB1被发现与CD 24和Siglec - g，唾液酸结合性免疫球蛋白样凝集素家族中的一员直接相关。
CD24 does not contain a cytosolic domain, and signals through Siglec-G, which contains an immune receptor tyrosine-based inhibitory motif (ITIM).
CD 24并不具有胞质内结构域，但通过Siglec - g传递的信号就包括了一个免疫受体酪氨酸相关抑制性基序immune receptor tyrosine - based inhibitory motif (ITIM)。
There are important variations in Siglec expression and function between humans and other species, among human populations, and across the age spectrum.
在人类与其他物种间、人类群体中及不同年龄段中，唾液酸样物质的表达和功能都有极其重要的变异。
The CD24-Siglec complex also recognizes heat shock proteins, another class of endogenous danger signals, but does not respond to lipopolysaccharide or poly-(dI:dC), two exogenous danger signals.
CD24-Siglec复合体还可识别另一种内源性危险信号热休克蛋白，但对脂多糖或poly-(dI:dC)这两种外源性危险信号均无反应。
The CD24-Siglec complex also recognizes heat shock proteins, another class of endogenous danger signals, but does not respond to lipopolysaccharide or poly-(dI:dC), two exogenous danger signals.
CD24-Siglec复合体还可识别另一种内源性危险信号热休克蛋白，但对脂多糖或poly-(dI:dC)这两种外源性危险信号均无反应。
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