Objective To investigate the synergistic analgesic action of rotundine combined with subthreshold dose of dolantin.
目的观察罗通定与阈下剂量哌替啶合用后对哌替啶镇痛作用的影响。
Objective to establish a UV method to determine the release degree of rotundine sustained-release tablets and to evaluate its in-vitro release behavior.
目的建立罗通定缓释片体外释放度测定方法，评价其体外释药行为。
Methods Ultraviolet spectrophotometry was applied to determine the release degree of rotundine sustained-release tablets with different release mediums.
方法用紫外分光光度法和体外释放度试验，考察罗通定缓释片在不同释放介质中和不同释放时间的累积释放度。
Conclusion The combined administration of dolantin and rotundine has significant synergistic action of analgesia, with reduced dose of dolantin and decreased incidence of addiction.
结论罗通定与阈下剂量派替啶合用可以增强镇痛效果，从而减少派替啶的用量，降低其药物依赖的发生概率。
Conclusion The combined administration of dolantin and rotundine has significant synergistic action of analgesia, with reduced dose of dolantin and decreased incidence of addiction.
结论罗通定与阈下剂量派替啶合用可以增强镇痛效果，从而减少派替啶的用量，降低其药物依赖的发生概率。
应用推荐