All had uncommon drug-resistance mutations that some resistance tests would miss.
所有5例均有少见的耐药突变，这些突变一些耐药检测无法检出。
There are many ingredients with antitumor, resistance mutations and antioxidant activity.
冬凌草中的许多成分具有抗肿瘤、抗突变、抗氧化活性。
Results This microarray could clearly differentiate the wide-type from mutated-type HBV with lamivudine-resistance mutations.
结果基因芯片技术监测能有效分辨野生型和突变型HBV。
Antibiotic resistance to originally effective means microbes antibiotic resistance mutations or, when microbes get resistance genes, it showed resistance.
抗菌素耐药性指微生物对原本有效的抗菌素产生耐药性，当微生物发生突变或获得耐药基因时，就产生了耐药性。
Slight mutations that allow a microorganism to resist the full killing power of a medicine are an evolutionary advantage that greatly expedites the development of drug resistance.
略微的突变即可使微生物具有抵抗力，使药物完全失去杀伤力，这种突变是一个进化优势，大大加快了耐药性的产生。
Bacteria that get mutations creating resistance to antibiotics are more likely to survive than are bacteria that remain sensitive to drugs.
获得突变的细菌产生对抗生素的抗性，它们比那些对药物敏感的非突变株幸存下来的几率更大。
The main drivers of resistance rates are not new mutations but rather antimicrobial selection pressure and transmission.
耐药比率的主要驱动因素不是新的突变，而是抗菌素的选择压力和耐药微生物的传播。
The viruses showed no mutations associated with resistance to the neuraminidase inhibitors, including oseltamivir (Tamiflu).
这些病毒显示没有与包括奥斯他韦(达菲)在内的神经氨酶抑制剂耐药性有关的突变。
Lo said that while his team was studying resistance, they expected to find secondary mutations in BRAF.
Lo说，虽然他的团队在研究耐药性，但是他们却希望存在BRAF的二次变异。
Presumably, resistance to Xalkori is being caused by disabling mutations in one or more of these genes.
可以推断，针对Xalkori的抗药性是由于这三个基因中的一个或多个发生了突变导致的结果。
Intensive food production, including the use of antibiotics in animals, creates additional pressures on the microbial world, leading to mutations and adaptations, including drug resistance.
集约型的食品生产，包括在动物身上使用抗菌素，给微生物世界造成了新的压力，导致变异和适应，包括耐药性。
Susceptible strains can become resistant either through mutations in existing genes or by acquiring a resistance gene from another organism that is already resistant.
敏感菌株可通过已有基因中的突变产生耐药性，或可通过从另一个已经具有耐药性的生物体获得耐药基因来产生耐药性。
Persistent bugs are different from those that develop antibiotic resistance through genetic mutations, but may be just as much of a problem.
这类持续存在的病原体虽然其本质不同于那些通过基因突变而产生抗药性的病原体，但是它们的存在都是不小的问题。
Objective To investigate the impact of non target gene mutations and reduced permeability of the outer membrane on quinolone resistance and multiple antibiotic resistance (mar) in Escherichia coli.
目的：探讨非靶位基因突变及外膜通透性改变对大肠杆菌喹诺酮类耐药和多重耐药的影响。
The Duke test examines the genes of HIV strains for mutations at certain positions that are known to be linked to drug resistance.
杜克试验在和抗药相关的当前已知位点检测HIV株的基因突变。
The TB test, called a line probe assay, costs less than $8 and detects mutations in bacterial DNA linked to drug resistance.
这种TB检测方法称为多列探针检测法，用不到8美元即可检出与耐药性相关的细菌DNA突变。
Resistance to Bt toxins in some insects is linked with mutations that disrupt a toxin-binding cadherin protein.
一些抗苏云金杆菌毒素的昆虫的抗性是和毒素结合钙粘蛋白的断裂相关。
Objective To investigate the effects of target gene mutations on the quinolones resistance in Escherichia coli.
目的探讨大肠埃希菌靶位基因突变对喹诺酮类药物耐药的影响。
After 240 weeks of therapy, the cumulative rates of HBV polymerase mutations, virologic resistance, and clinical resistance were 29%, 20%, and 11%, respectively.
经过240周的治疗后，HBV聚合酶的蓄聚率、病毒的耐药率和临床耐药率分别是29%，20%和11%。
Mutations of specific amino acids in ALS have been known to confer resistance to ALS-inhibiting herbicides such as sulfonylureas and pyrimidinyl carboxy (PC) herbicides.
已知乙酰乳酸合酶特定氨基酸突变可以提高对抑制乙酰乳酸合酶类除草剂的抗性，如碘酰脲类和嘧啶羧酸类除草剂。
These results extend the landscape of genetic alterations in leukaemia, and identify mutations targeting transcriptional and epigenetic regulation as a mechanism of resistance in ALL.
这些结果扩展了白血病的基因变异谱，确定后天调控与转录靶向突变为ALL的耐药机制。
Nucleoside analogues are currently the main drug therapy against HBV infection. However, this type of therapy can cause gene mutations in HBV that result in drug resistance.
核苷类药物是目前抗乙型肝炎病毒(HBV)的主要药物，但它可引起HBV基因的变异，从而引起耐药。
These results suggest that the emergence of KRAS mutations is a mediator of acquired resistance to EGFR blockade and that these mutations can be detected in a non-invasive manner.
这些发现提示，KRAS的突变是获得性EGFR阻滞治疗抵抗的媒介；而且，这些突变可以用非侵入的方法检测到。
The resistance to quinolones in clinical isolates of Pseudomonas aeruginosa is due to the mutations of two types of topoisomerase plus efflux pump.
结论铜绿假单胞菌的耐药性日趋严重，两类拓扑异构酶基因突变和泵出机制形成了铜绿假单胞菌对喹诺铜类药物耐药的主要机制。
The test, which detects genetic changes, or mutations, in HIV, also may help scientists understand how the constantly evolving virus develops drug resistance, Gao said.
Gao说，监测HIV基因改变或突变的试验也可能帮助科学家明白不断进化的病毒是如何形成药物耐药的。
Mutations associated with resistance in viral genome result in decrease of drug sensitivity to human immunodeficiency virus (HIV).
HIV耐药性是指由于发生特定的病毒基因突变，导致病毒对药物敏感性下降的现象。
The molecular mechanism of resistance to the antifolates has been well characterisied and is due to structural changes in the target enzymes resulting from the point mutations of DHFR or DHPS gene.
抗叶酸类抗疟药的抗药性机制已基本搞清，与其作用靶酶二氢叶酸还原酶或二氢蝶酸合成酶基因点突变相关。
Activating mutations in downstream genes of the epidermal growth factor receptor (EGFR) pathway may cause anti-EGFR resistance in patients with colorectal cancers.
表皮生长因子受体(EGFR)通路下游基因的激活突变可以引起结直肠癌患者抗egfr耐药。
Activating mutations in downstream genes of the epidermal growth factor receptor (EGFR) pathway may cause anti-EGFR resistance in patients with colorectal cancers.
表皮生长因子受体(EGFR)通路下游基因的激活突变可以引起结直肠癌患者抗egfr耐药。
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