The largest group of this family is the protein kinases.
该家族的最主要成员是蛋白激酶。
Protein kinases and phosphatases play a central role in cellular signaling.
蛋白激酶与蛋白磷酸酶在细胞信号传递中起着重要作用。
The largest group of kinases are protein kinases, which act on and modify the activity of specific proteins.
蛋白激酶是数量最多的一类激酶，作用和修饰特定蛋白的活性。
Signalling cascades consisting of protein kinases play important roles in hormone signal transduction pathways of plants.
蛋白质激酶的磷酸化级联放大系统在激素的信号转导中起重要作用。
The present invention relates to compounds of formula (I) useful as inhibitors of protein kinases, particularly of JAK family kinases.
本发明涉及可用作蛋白激酶、特别是JAK家族激酶的抑制剂的式(i)化合物。
If one is really, for instance, captivated by the biochemistry of protein kinases, you don't necessarily have to work on kinases in oncogenesis.
比如说，如果你真正着迷于蛋白激酶生物化学，你不一定要在肿瘤学范围内研究激酶。
Protein kinases play important roles in plant growth and development, hormone response as well as in response to abiotic and biotic stress.
蛋白激酶在植物生长、激素调节和生物与非生物逆境胁迫反应中起着重要的作用。
To investigate the expression and activation of mitogen-activated protein kinases in non-small cell lung cancer and its clinical significance.
目的：探讨丝裂原活化蛋白激酶在非小细胞肺癌中的表达及其临床意义。
However, many cancer cells in vitro are resistant to apoptosis-inducing effect of TRAIL, which are closely related to its receptors, protein kinases and some related proteins.
部分肿瘤细胞对TRAIL的敏感性较差，其原因与TRAIL的受体、信号转导途径激酶以及相关蛋白存在密切联系。
Here, we will review several kinds of protein kinases as potential targets for CVDs and some difficulty in identifying a protein kinase as a putative therapeutic target for CVDs.
在此，我们将总结一些已经能用于心血管疾病的蛋白激酶靶位，以及一些鉴定与心血管疾病有关蛋白激酶假定的治疗靶位的难点。
Protein kinases are enzymes that turn other proteins on or off. The IKKE protein kinase appears to target proteins which, in turn, control genes that regulate the mouse metabolism.
蛋白激酶是一种可以控制其他蛋白开或是关的酶，IKKE蛋白激酶看起来是作用于调控小鼠代谢的基因的。
This review focuses on the regulation of the paracellular pathway and provides an overview of the mechanisms that protein kinases regulate paracellular permeability in inflammation.
该文对上述蛋白激酶在微血管通透性中作用机制的研究进展进行综述。
The company has its focus on nucleotide chemistry with special emphasis on cyclic nucleotide-based modulators of respective protein kinases, phosphodiesterases and ion channels, etc.
公司主要关注核苷酸化学，尤其侧重环状核苷酸为基础的各种蛋白激酶、磷酸二酯酶和离子通道等的抑扬调节剂。
The reversible phosphorylation of protein kinase plays important roles in many signal identifying and transfer in cell. The protein kinases mainly catalyse phosphorylation of proteins.
蛋白质的可逆磷酸化过程在细胞的信号识别与转导中起重要作用，蛋白激酶主要催化蛋白质的磷酸化作用。
Activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis (1). P53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro (2, 3).
p53的激活能够引起细胞周期捕获和DNA修复或细胞凋亡(1)。离体或者在体情况下，p 53可以在多个位点被几个蛋白激酶进行磷酸化(2,3)。
Specific signaling motifs include not only sequences that are recognized by protein kinases (1), but also those that are recognized by phosphorylation-dependent binding proteins such as 14-3-3 (2).
特异的信号基序不仅包括蛋白激酶可以识别的序列(1)，也包括那些能够被磷酸化依赖结合蛋白如14-3-3识别的序列(2)。
Receptor tyrosine protein kinase is one of key kinases in cell signal transduction and plays an important role in the process of cell growth, development and functions regulated by growth factors.
受体酪氨酸蛋白激酶是细胞信号转导进行的关键信号酶，在生长因子调控细胞生长、发育与功能的过程中起着重要的生理作用。
Kinases are protein switches that activate other proteins by adding a phosphate group to them via a process called phosphorylation.
激酶是蛋白开关，它们通过一个称为磷酸化的过程将磷酸基团结合到其他蛋白上并激活这些蛋白。
K protein contains multiple modules that, on one hand, bind kinases while, on the other hand, recruit chromatin, transcription, splicing and translation factors.
蛋白包含多种分子，不但可以结合激酶，还能募集染色质、转录、剪切和翻译因子。
CONCLUSIONS AG1109 not only was an effective inhibitor of protein tyrosine kinases, but also was a novel potent inhibitor of protein kinase CK2.
结论：AG110 9不仅是酪氨酸蛋白激酶的抑制剂，而且是一种十分有效的蛋白激酶CK2的抑制剂。
Anticancer therapies targeting HER2 have shown promise and become a focus, including monoclonal antibody, tyrosine kinases inhibitor, tumor vaccine, fusion protein.
包括单克隆抗体、酪氨酸激酶抑制剂、融合蛋白、瘤苗在内，以her2为靶点的抗肿瘤治疗研究成为热点，并显示出广阔的应用前景。
Receptor tyrosine kinases (RTK), G protein-coupled receptors (GPCR) and ion channel receptors are main cell surface receptors.
酪氨酸激酶型受体、G蛋白偶联受体和离子通道型受体是细胞表面三类主要受体。
Protein tyrosine kinases play an important role in signal transduction pathways in regulating a number of cellular functions.
蛋白质酪氨酸在一系列细胞活动的信号转导途径中起着重要的作用。
Such lists can be projected onto prior knowledge of kinase-substrate interactions to infer the list of kinases associated with a specific protein list.
这些列表能够被投射到激酶-底物相互作用的先验知识，以推断与一个特定蛋白质列表相关的激酶列表。
The protein showed no similarity to other pathogenesis-related proteins but did show homology to the extracellular domain of plant cysteine-rich receptor-like kinases.
序列分析表明，其结构与所有已知的抗真菌蛋白不同，而与富含半胱氨酸的植物类受体激酶的胞外结构域相似。
The protein showed no similarity to other pathogenesis-related proteins but did show homology to the extracellular domain of plant cysteine-rich receptor-like kinases.
序列分析表明，其结构与所有已知的抗真菌蛋白不同，而与富含半胱氨酸的植物类受体激酶的胞外结构域相似。
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