Within each synapse is a set of proteins, which, like the components of an engine, bind together to build a molecular machine called the postsynaptic density - also known as the PSD.
每个神经突触都有拥有一系列蛋白,它们像机器的零件一样,结合在一起,搭建出一个被称为突触后致密区(postsynaptic density PSD)的分子机器。
Dendritic spines are functional protrusions on neuron dendrites and generally act as postsynaptic sites to form integral synapses with axon terminals.
树突棘是神经元树突上的功能性突起结构,通常作为突触后成份与投射来的轴突共同构成完整的突触连接。
Mining the postsynaptic proteome now gives researchers a strategic entry point, and the rest of us a front row seat to witness neuroscience unravel the complexity of human brain disorders.
现在开发这些突触后蛋白组给了研究者一个战略切入点,其他人则可以坐在前排位置,见证神经科学展开人类大脑疾病的内在奥秘。
The recordings of postsynaptic currents were performed by using the whole-cell voltage-clamp method.
采用全细胞电压钳记录技术,给予选择性受体阻断剂以分离不同的突触后受体电流。
Objective To study the expression and distribution of postsynaptic density protein-93 (PSD-93) after spinal cord injury (SCI).
目的探讨突触后密度蛋白- 93 (PSD - 93)在脊髓损伤(SCI)后的表达变化以及定位情况。
The visual patch-clamp method can accurately assess synaptic transmission by measuring postsynaptic currents of the dorsal horn neurons.
可视膜片钳方法可以准确测量脊髓背角神经元的突触后电流从而研究初级传入突触的传递过程。
Moreover, we found that presynaptic but not postsynaptic inactivation of presenilins alters short-term plasticity and synaptic facilitation.
而且,我们发现突触前灭活早老蛋白而突触后未灭活时改变了突触的短期可塑性和突触易化。
A major challenge in studying the synapse is how to tell what observed effects are due to presynaptic factors and which to postsynaptic ones.
研究突触最大的困难在于如何区辨所观察到的反应是来自突触前或突触后因子所导致。
Neurotransmitter receptors mediate signal transduction at the postsynaptic membrane of synaptic connections between neurons in the nervous system.
大脑中神经元突触间的信号传递是由许多神经递质受体介导的。
Objective To explore the effect of pentylenetetrazol(PTZ)-kindled epilepsy on rats learning, memory and the expression of postsynaptic density 95(PSD-95).
目的探讨戊四氮诱导癫痫对大鼠空间学习记忆功能的影响及海马突触后致密物95(PSD-95)的表达变化。
Especially, there were TH-like positive cell bodies and axonal endings which formed synapses as presynaptic elements with th negative postsynaptic structures.
免疫电镜还显示有TH阳性神经元胞体和轴突末梢,后者可作为突触前成分与TH阴性结构形成突触。
As compared with the hypoxia group, 2% and 4% sevoflurane obviously prolong the disappeared time of the postsynaptic population spike due to hypoxia (P< 0.05).
与缺氧组相比,2%和4%七氟烷均明显延迟缺氧所致的诱发群峰电位消失时间(P<0.05);
At the holding potential of 0 mV, spontaneous inhibitory postsynaptic currents (IPSCs) and dorsal root stimulation-evoked IPSCs were recorded as outward currents.
在钳制电压为0毫伏条件下,记录自发的和背根刺激引起的抑制性突触后电流。
The previous studies indicated it produced anesthetic effect through its mimic GABA action, which enhanced central inhibition mediated by postsynaptic GABAa receptors.
以往研究认为其具有拟gaba样作用,通过增强突触后gaba_a受体介导的中枢抑制而产生麻醉作用。
Phosphorylation of postsynaptic density proteins remains a largely unexplored mechanism in activity-dependent regulation of dendrite development and synaptic function.
在树突发育和突触功能活性依赖的调节过程中,突触后致密蛋白磷酸化的机制仍然是未知的领域。
The results indicate that dorsal column postsynaptic neurons possess a relatively simplified geometric organization and a considerable complexity in their local synaptic circuitry.
结果提示,背索突触后神经元具有相对简化的几何构筑和相当复杂的局部突触回路。
Objective: To study the relationship between the synaptic types of the fast adapting lingual afferent terminals and the postsynaptic dendrites in the principal trigeminal nucleus in cats.
目的 :研究舌快反应传入纤维终止于三叉神经感觉主核形成的突触类型及与突触后膜树突的关系 ,为神经生理学研究和神经解剖学研究提供参考资料。
The equations of the model, corresponding to postsynaptic potentials, receptor potentials, initial segment graded potentials and the impulse train along the axon respectively, have been given.
模型方程分别对应于突触后电位、感受器电位、始段分级电位和轴突上的的脉冲系列,每个方程都具有明确的生理意义。
The abnormal metabolism and excess release of Glutamic acid as well as high-frequency stimulation to the postsynaptic receptor induce excitatory neural toxicity, resulting in the death of neurons.
因谷氨酸代谢异常,过度释放和对突触后受体的高频刺激,引起了兴奋性神经毒性,导致神经元死亡。
Maturation of presynaptic transmitter secretion machinery and trafficking of postsynaptic receptors are two critical steps in synaptogenesis and synaptic development of central nervous system (CNS).
突触前递质释放装置的发育成熟和突触后受体的转运是中枢神经系统突触发育过程中非常重要的两个方面。
Postsynaptic potentials manifested current effect and frequency dependency and their IPSP displayed a prolonged inhibition.
突触后电位表现电流效应和频率依赖性,其IPSP具有长时程的抑制作用。
Postsynaptic dense area and the close relationship between synaptic plasticity are essential for the maintenance of synaptic function properly.
突触后致密区与突触可塑性的关系十分密切,对于维持突触发挥正常功能至关重要。
Postsynaptic dense area and the close relationship between synaptic plasticity are essential for the maintenance of synaptic function properly.
突触后致密区与突触可塑性的关系十分密切,对于维持突触发挥正常功能至关重要。
应用推荐