Objective:To synthesize pioglitazone hydrochloride.
目的：合成盐酸吡格列酮。
The situation has not been the same with pioglitazone.
这种情况与吡格列酮不同。
No difference between rosiglitazone and pioglitazone was apparent.
罗格列酮和匹格列酮间无明显差别。
It was financed in part by Takeda Pharmaceuticals, maker of pioglitazone.
它的部分经费由吡格列酮的制造商武田制药提供。
The study by Lincoff et al. reviewed the data from clinical trials of pioglitazone.
来自Lincoff等的研究，重新回顾了来自匹格列酮的一些临床试验的数据。
Pioglitazone clearly has fallen on the side of cardiovascular benefits or very close.
吡格列酮明显倾向于心血管获益方面或者非常接近。
Rosiglitazone and pioglitazone are part of a group of drugs called thiazolidinediones.
罗格列酮和吡咯列酮同属噻唑烷二酮类。
Has some of the bad press and issues with rosiglitazone unfairly affected pioglitazone?
有关罗格列酮的一些负面新闻是否会对吡格列酮有影响？
We did not observe similar associations in a secondary analysis evaluating pioglitazone.
我们在第二次罗格列酮分析评估中没有看到类似的相关性。
Beginning in 1999, rosiglitazone maleate and pioglitazone hydrochloride were approved for use.
从1999年开始，马来酸罗格列酮和盐酸匹格列酮被批准使用。
When you look at the composite meta-analysis data for pioglitazone, it falls on the good side.
当你观察吡格列酮复合的荟萃分析数据，它倾向于好的方面。
"The PROACTIVE data went in the right direction, so I would say pioglitazone was probably safe," he said.
在正确的方向显示积极的数据，所以我要说匹格列酮类药物可能是安全的。
International Diabetes: Does pioglitazone have more favorable effects on serum lipids than rosiglitazone?
《国际糖尿病》：吡格列酮对血脂的作用是否优于罗格列酮？
Serious heart failure is increased by pioglitazone, although without an associated increase in mortality.
吡格列酮增加严重的心衰，虽然死亡率没有增加。
Objective To observe the effects of different dosages of pioglitazone on uninephrectomized diabetic rats.
目的观察不同剂量盐酸吡咯列酮对单肾切除糖尿病大鼠模型慢性肾脏损害的作用。
My personal view is that pioglitazone should stay on the market and just be used a little more carefully.
我个人的观点是吡格列酮应当在市场上保留，只用应用时多点儿谨慎。
Pioglitazone was tested in combination with a sulfonylurea, insulin, or metformin in 8 trials (8501 patients).
吡格列酮联用磺脲类、胰岛素或者二甲双胍用于8项试验(8501个病人)。
TABLE 2 lists the clinical outcome measures in the pioglitazone and control groups of the 19 individual trials.
表2列举了吡格列酮及对照组共19项试验的临床结果。
Serious heart failure is increased in patients on pioglitazone, although there is no associated increase in mortality.
在使用匹格列酮的患者中，严重的心力衰竭增加，但是没有引起与之相关的死亡率的增加。
Conclusion Pioglitazone and fenofibrate have different influences on energy homeostasis and body fat distribution in rats.
结论吡格列酮、非诺贝特对大鼠能量代谢及体脂分布的影响不同。
Objective Observe the effect of pioglitazone on insulin sensitivity and lipid metabolism in type 2 Diabetes Mellitus Patients.
目的观察吡格列酮对2型糖尿病患者胰岛素敏感性和脂代谢的影响。
About half of the group was given 45 milligrams of pioglitazone daily for six months, while the other half received a placebo.
一半组员6个月期间每天服用45毫克吡格列酮，而剩下一半为安慰剂治疗。
Insulin sensitivity in the liver improved by 48 percent in the pioglitazone group, compared to 14 percent in the placebo group.
与安慰剂组的14%相比，服用吡格列酮组肝脏的胰岛素敏感型改善了48%。
Conclusion Pioglitazone can obviously decrease UAER of patients with early DN, and have the function of lowering the blood sugar.
结论吡格列酮可明显减少早期糖尿病肾病患者的UAER，并有显著降低血糖的作用。
Conclusions The increased expression of R2 mRNA may play a important role in pioglitazone-induced insulin sensitivity amelioration.
结论R2很可能是胰岛素增敏剂吡格列酮改善肝脏胰岛素敏感性的重要作用机制之一。
Objective To study whether pioglitazone therapy ameliorates endothelial dysfunction in pre-diabetic patients and the mechanism of it.
目的观察吡格列酮治疗糖尿病前期患者血管内皮细胞功能的变化及其可能的机制。
International Diabetes: Do rosiglitazone and pioglitazone have different or similar properties in respect to their cardiovascular profiles?
《国际糖尿病》：罗格列酮和吡格列酮对心血管的影响是否有所差别？二者有何相似性？
This finding, however, might be an underestimate of the benefit of pioglitazone, since events subsequent to the initial one are also reduced.
但是，这一发现可能低估了匹格列酮的益处，因为继发于初始事件的继发事件也被减少。
Risk of Acute Myocardial Infarction, Stroke, Heart Failure, and Death in Elderly Medicare Patients Treated With Rosiglitazone or Pioglitazone.
使用罗格列酮或吡格列酮治疗的老年医保患者发生急性心肌梗塞，卒中，心力衰竭和死亡的危险性。
Pioglitazone is a thiazolidinedione that ameliorates insulin resistance and improves glucose and lipid metabolism in type 2 diabetes mellitus.
吡格列酮是一种噻唑烷二酮类药物，可以改善胰岛素敏感性并且改善2型糖尿病的糖脂代谢。
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