OBJECTIVE To study the synthesis of pemetrexed.
目的研究培美曲塞的合成方法。
OS benefit is obtained with early use of pemetrexed but not docetaxel;
早期应用培美曲赛对OS是获益的而不是多西他赛；
Pemetrexed disodium is the only agent for the treatment of malignant pleural mesothelioma(MPM).
培美曲塞二钠是唯一治疗恶性胸膜间皮瘤（MPM）的药物。
Patients with the squamous subtype did not seem to benefit with pemetrexed confirming what has been shown in other studies.
鳞癌患者好像并未从培美曲塞中获益，与其它类似研究结果一致。
In this review, an overview concerning about the clinical development of pemetrexed on advanced colorectal cancer was given.
现就培美曲塞治疗晚期大肠癌的临床研究进展作一综述。
The largest disparities were in the use of the new colorectal and lung cancer drugs: bevacizumab, cetuximab, erlotinib and pemetrexed, the study found.
差别最为悬殊的是新型抗结肠直肠癌及肺癌药物的应用，这些药物包括贝伐单抗、西妥昔单抗、埃罗替尼及培美曲塞。
Pemetrexed is a multitargeted antimetabolite that has shown activity in malignant pleural mesothelioma and NSCLC, which has been approved in more than 70 countries.
培美曲塞是一种多靶点的抗代谢类药物，目前已经在70余个国家批准上市，用于治疗恶性胸膜间皮瘤和非小细胞肺癌。
It should be noted that the ATLAS patient population had almost no squamous cell carcinoma, in contrast to the populations of the JMEN pemetrexed trial and the SATURN erlotinib trial.
值得注意的是ATLAS试验纳入的绝大多数病人为非鳞状细胞癌，不同于培美曲赛的JMEN试验和厄洛替尼的SATURN试验。
As the current evidence shows, pemetrexed has similar efficacy to docetaxel for advanced NSCLC patients, but it has fewer side effects of neutropenia, febrile neutropenia and alopecia.
结论当前证据显示，培美曲塞与多西紫杉醇治疗晚期NSCLC的疗效相当，但可减少中性粒细胞减少、粒细胞性发热和脱发等不良反应。
The latest progresses of pemetrexed in first-line treatment, second-line treatment, maintenance treatment, and adjuvant chemotherapy of non-small cell lung cancer are reviewed in the article.
本文对此药在非小细胞肺癌一线、二线、维持治疗和辅助放化疗方面最新的研究进展进行了回顾和展望。
Pemetrexed is a multi-target anti-folate agents, by inhibiting the activity of enzymes which are necessary for folic acid synthesis to inhibit DNA replication and thus inhibit the tumor growth.
培美曲塞是一种多靶点抗叶酸制剂，通过抑制合成叶酸所必需的酶的活性来抑制DNA的复制从而抑制肿瘤生长。
Pemetrexed is a multi-target anti-folate agents, by inhibiting the activity of enzymes which are necessary for folic acid synthesis to inhibit DNA replication and thus inhibit the tumor growth.
培美曲塞是一种多靶点抗叶酸制剂，通过抑制合成叶酸所必需的酶的活性来抑制DNA的复制从而抑制肿瘤生长。
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