The protein drug PEGylation technology is a technology that chemically modifies protein drug by polyethylene glycol derivatives.
蛋白药物聚乙二醇化技术是指一项利用聚乙二醇衍生物对蛋白药物进行化学修饰的技术。
The degree of PEGylation had no obvious influence on the disruption of endosomal compartments and DNA releasing from endosomes via the proton sponge mechanism.
接枝PEG的量对引起的内含体破裂并释放DNA的质子海绵效应不会产生明显影响。
The importance of chemistry of protein and peptide pegylation has attracted more and more attentions as more PEG conjugates have reached late phase clinical trials.
随着聚乙二醇化蛋白质和肽类进入临床试验阶段，聚乙二醇化化学越来越引起研究者的重视。
CONCLUSION the biologic half-life of RTA can be prolonged through PEGylation. And RTA modified by PEG can avoid the take-ups of liver and spleen, at the same time accumulate in tumor tissues.
结论通过聚乙二醇的修饰，使RTA生物半衰期大大延长，且修饰后能避免肝脏、脾脏的摄取，并靶向到肿瘤组织。
CONCLUSION the biologic half-life of RTA can be prolonged through PEGylation. And RTA modified by PEG can avoid the take-ups of liver and spleen, at the same time accumulate in tumor tissues.
结论通过聚乙二醇的修饰，使RTA生物半衰期大大延长，且修饰后能避免肝脏、脾脏的摄取，并靶向到肿瘤组织。
应用推荐