In the article, the researchers use a variety of techniques to define how IPA-3 interacts with PAK1.
在文章中,研究人员使用了多种技术,以确定IPA - 3和PAK1如何相互作用。
Our tests also demonstrate that IPA-3 is highly selective for PAK1, which means that it is less likely it will also turn off other kinases unintentionally.
我们的测试也表明,IPA - 3对PAK1有高度选择性,这意味着它是不太可能随意的关闭其他激酶。
"We found definitive proof that IPA-3 fit into and binds to PAK1's autoregulatory domain, the part of the enzyme where it can, essentially, shut itself off when necessary," Peterson says.
“我们发现确切证据证明IPA - 3绑定在PAK1的自我调节域,部分的酶会在需要时关闭自己”彼得森说。
"We found definitive proof that IPA-3 fit into and binds to PAK1's autoregulatory domain, the part of the enzyme where it can, essentially, shut itself off when necessary," Peterson says.
“我们发现确切证据证明IPA - 3绑定在PAK1的自我调节域,部分的酶会在需要时关闭自己”彼得森说。
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