Objective: To analyse the significance and relationship between p53 gene mutation and the expression of mutant type p53 gene protein in the laryngeal carcinomas.
目的：探讨喉癌P53基因突变与突变性P 53基因蛋白表达之间的相互关系及意义。
Methods:Immunohistochemistry and PCR-SSCP were used to detect the expression of P53 protein and p53 gene mutation in 32 cases of TSCC and 10 cases of tongue leukoplakia.
方法：应用免疫组织化学和聚合酶链反应—单链构象多态性分析（PCR-SSCP）检测10例舌白斑和32例舌癌，并结合临床资料进行分析。
Objective To observe the relationship between P53 gene mutation and malignant eyelid tumor.
目的探讨P 53基因突变与眼睑恶性肿瘤发生的关系。
The P53 gene mutation site in osteosarcoma was mostly in GC sequence of exon, especially in exon 7, which was different with other tumors.
骨肉瘤p 53基因多位于外显子GC序列，尤其是外显子7，有别于其他肿瘤好发位点。
The detection of P53 gene mutation plays an important role in predicting the malignant progression of bladder cancer and in early detection of bladder cancer recurrence.
P 53基因突变的检测对预测膀胱癌的进展，复发的早期诊断具有重要的临床意义。
The detection of P53 gene mutation plays an important role in predicting the malignant progression of bladder cancer and in early detection of bladder cancer recurrence.
P 53基因突变的检测对预测膀胱癌的进展，复发的早期诊断具有重要的临床意义。
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