Controversy exists concerning the advantages of the different methods of enteral feeding, as well as the oral stimulation and sucking during gavage feeding in preterm infants.
因而喂养问题已成为人们普遍关注的重要问题之一，而对早产儿各种喂养方法的利弊及鼻胃管喂养时是否需要口腔刺激一直存在争议。
Objective To investigate the frog oral mucomembranous ciliotoxicity of Compound Shuangxin Spray and its stimulation on the rat nasal mucosa.
目的考察复方双辛喷雾剂对蛙口腔黏膜纤毛的影响及对大鼠鼻腔黏膜的刺激性。
METHODS Formalin test in mice, tooth pulp stimulation procedure in rabbits and human oral pain were used.
方法动物实验采用兔齿髓刺激法和小鼠福尔·马林实验，临床疼痛评定采用视觉模拟评分法。
Its acute toxicity was tested by single oral injection, and the acute skin stimulation test was conducted directly on rabbits' skin.
急性经口毒性试验采用一次灌胃，急性皮肤刺激试验在家兔皮肤上进行。
Conclusion: It was suggested that MMP-2 expression is increased by paracrine stimulation mediated by soluble factors originated from oral CAFs and MMP-9 expression requires direct cell-cell contact.
结论：MMP - 2表达增加可能受到源自口腔癌相关成纤维细胞可溶性因子的旁分泌介导，而MMP - 9表达可能需要口腔癌细胞与癌相关成纤维细胞的直接接触。
Conclusion: It was suggested that MMP-2 expression is increased by paracrine stimulation mediated by soluble factors originated from oral CAFs and MMP-9 expression requires direct cell-cell contact.
结论：MMP - 2表达增加可能受到源自口腔癌相关成纤维细胞可溶性因子的旁分泌介导，而MMP - 9表达可能需要口腔癌细胞与癌相关成纤维细胞的直接接触。
应用推荐