Methods: Fibroblast and epithelial cells of normal oral mucosa and OLK were cultured in vitro.
方法：体外培养正常和口腔白斑上皮细胞及成纤维细胞；
Conclusion: Ttelomerase could act as a surrogate endpoint biomarker for oral chemoprevention during OLK carcinogenesis.
结论：端粒酶可以作为口腔白斑癌变化学预防的替代性终点标记物监测口腔白斑癌变。
Mucosal epithelium tissues of OLK local lesion were collected and examined for the expression of OPN by immunohistochemical method.
采集olk病损局部黏膜组织标本，采用免疫组织化学方法检测黏膜上皮细胞OPN表达。
Objective To explore the expression of osteopontin (OPN) in oral mucosal epithelium of oral local lesion in patients with oral leukoplakia (OLK).
目的研究口腔白斑(olk)患者病损局部黏膜上皮细胞骨桥蛋白(OPN)表达情况。
In OLK patients with sever epithelium dysplasia, the Numbers of OPN positive cells increased obviously and the positive cells spread the whole epithelial cell stratum.
OLK组伴重度上皮异常增生组织中opn阳性细胞数量明显增多且分布于上皮全层。
In OLK patients with sever epithelium dysplasia, the Numbers of OPN positive cells increased obviously and the positive cells spread the whole epithelial cell stratum.
OLK组伴重度上皮异常增生组织中opn阳性细胞数量明显增多且分布于上皮全层。
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