Novavax, another American start-up, has had similarly promising results using “virus-like particles” (made of non-infectious viral proteins purged of genetic material).
美国另一家新型企业—诺瓦瓦克斯公司用类病毒物质(即未感染的病原蛋白,且去掉其遗传物质)得到了差不多的结果,都很有前景。
Increased risk of Kaposi's sarcoma and non-Hodgkin's lymphoma was associated with lower CD4 count, higher HIV viral load and a lack of combination antiretroviral therapy (cART).
CD4计数低、艾滋病病毒载量高以及有无结合抗逆转录病毒治疗(cART)均会使卡波西氏肉瘤和非霍奇金淋巴瘤患病风险增加。
DNA condensation is a common physiological phenomenon in nature and also a key step in non-viral vector-mediated gene transfection.
DNA缩合不仅是自然界常见的生理现象,也是非病毒载体介导基因转染的关键步骤。
Polyaminoacid materials are widely researched as non-viral gene vectors because of the advantages, such as biodegradation, low cytotoxicity and so on.
聚氨基酸材料由于可生物降解性,低毒性等特点而被广泛的作为非病毒性基因载体材料的研究。
They comprise the viral capsid named P1. The non-replicating DNA vaccine, encoding P1 and the processing (3c) proteinase, was reported to produce detectable antiviral immune response.
据报道,编码p1和病毒蛋白酶3c的非复制型DNA疫苗可以诱导产生抗病毒免疫应答。
NS2 protein as a non-structural protein mainly involved in viral DNA replication and regulation of gene expression.
NS2蛋白作为非结构蛋白,主要参与病毒DNA的复制及调节基因的表达。
In recent years, many kinds of cationic lipids, oligopeptides and polymers have been developed as non-viral gene delivery materials.
近年来,许多阳离子脂质体、阳离子多肽及阳离子聚合物被用作非病毒类的基因输送载体。
The recent topic has been focused on the new non-viral vectors.
因此寻找新的非病毒载体成为目前的研究热点。
With the development in non-viral gene delivery systems, chitosan-DNA complex is being widely applied in prophylaxis and treatment of various diseases.
随着非病毒基因投递系统研究的不断深入,壳聚糖- DNA复合物已被广泛应用于各种疾病的基因预防和治疗中。
Inorganic nanoparticles as non-viral gene carriers have caught much attention because of their good stability, biocompatibility, safety, efficiency and non-immunogenicity.
无机纳米颗粒类非病毒型基因载体因其稳定性好、生物亲和性好、安全、有效、无免疫原性等优点,已引起广泛关注。
Conclusion LPD could be prepared easily with small particle sizes and high transfection activities. LPD may be good non-viral vectors for applications in gene delivery.
结论LPD是一种制备工艺简单、体外稳定性好、转染率高,具有应用潜力的非病毒载体系统。
'We show for the first time that it is now possible to efficiently deliver genes into stem cells, particularly those of the immune system, using non-viral gene delivery', says Marinee Chuah.
Marinee Chuah说:“我们首次展示了使用的非病毒基因传递方式使基因有效的植入干细胞,特别是进入那些免疫系统”。
Chitosan is the natural biological polysaccharide which has been proven to be the potentially promising non-viral vector materials.
壳聚糖作为一种天然生物多糖物质,已被证明是具有潜在前景的非病毒载体材料。
Recently, researchers pay more and more attention to non-viral vector.
近年来,非病毒载体的研究越来越受到重视。
The invention also relates to the pharmaceutical compositions containing the non-viral vectors and the expression type recombinant and their use.
本发明还涉及包含所述非病毒载体和所述表达型重组体的药物组合物及其应用。
Conclusion DWI is a valuable method for in vivo and non-invasive assessment of the disease activity and liver fibrosis of chronic viral hepatitis.
结论DWI技术能评价活体慢性病毒性肝炎的活动度和纤维化程度。
The invention also relates to application of the composite medicine and the independent non-viral vector in the treatment of the malignant tumor.
本发明还涉及此复合药物及单独的非病毒载体在恶性肿瘤治疗中的用途。
We and others have pointed this out recently for several liver diseases, including chronic viral hepatitis B and c, alcoholic liver disease, and non-alcoholic fatty liver disease.
我们及其他研究者最近得出的这一结论适用于多种肝脏疾病,包括乙型慢性病毒性肝炎、丙型慢性病毒性肝炎、酒精性肝病和非酒精性脂肪肝。
Results The differences in ALT baselines between viral responding and non-responding groups were significant at treatment time and at the end of the follow-up period.
病毒学应答无论在治疗期还是随访结束时,应答组与非应答组之间的ALT水平差异均有统计学意义。
Results The differences in ALT baselines between viral responding and non-responding groups were significant at treatment time and at the end of the follow-up period.
病毒学应答无论在治疗期还是随访结束时,应答组与非应答组之间的ALT水平差异均有统计学意义。
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