Microsphere size, which has a significant effect on drug release rate, can potentially be varied to design a controlled drug delivery system with desired release profile.
微球大小对药物释放率有很重要的影响，人们认为可以改变其大小以建立一个药物释放符合需要能够控制药物释放的体系。
Objective: To optimize the preparation of miconazole nitrate malic acid-chitosan microsphere with uniform test design, the stability and release of microsphere were studied.
目的：以均匀设计法筛选优化硝酸咪康唑苹果酸化壳聚糖微球的制备工艺，提供可控性及预测性，并对微球稳定性和药物释放规律进行研究。
Objective: To optimize the preparation of miconazole nitrate malic acid-chitosan microsphere with uniform test design, the stability and release of microsphere were studied.
目的：以均匀设计法筛选优化硝酸咪康唑苹果酸化壳聚糖微球的制备工艺，提供可控性及预测性，并对微球稳定性和药物释放规律进行研究。
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