Matrix metalloproteinases (MMPs) has been viewed as a promising target in tumor therapy in recent years due to their key role in tumor growth, angiogenesis, invasion and metastasis.
近几年来，基质金属蛋白酶因在肿瘤的生长、转移和血管生成等多个环节中发挥着重要作用而成为肿瘤治疗研究中引人注目的新靶点。
The tumor cells produce a whole range of proteases that degrade the proteins of the extracellular matrix that hems them in, part of which is the basement membrane.
这些肿瘤细胞产生了一整系列的蛋白酶，能降解包围它们的细胞外基质蛋白，这也是部分的基底膜。
Matrix metalloproteinases (MMPs) has been viewed as a promising target in tumor therapy due to their key role in tumor growth, angiogenesis, invasion and metastasis.
基质金属蛋白酶(MMP)因其在肿瘤的生长、转移和血管生成等多个环节中发挥着重要作用而成为肿瘤治疗研究中引人注目的靶点。
BACKGROUND: Chondroitin sulfate is the important component of cell matrix, it can accelerate the proliferation of tumor cells and restrain its transfer.
背景：硫酸软骨素是细胞基质的重要成分，可促进肿瘤细胞的增殖，抑制其转移。
Those genes with increased expression level in aging lung mainly related to cytoskeleton or extracellular matrix, inflammation or stress response, tumor, signal transduction and so on.
上调为主的有：细胞骨架和胞外基质、炎性应激反应、肿瘤相关、信号转导等；
Objective To evaluate the expression of Matrix metalloproteinase 2 (MMP 2) in colorectal tumor epithelial cells and mesenchymal cells.
目的探讨结直肠癌肿瘤实质及肿瘤间质中基质金属蛋白酶-2 (MMP - 2)的表达及其病理学意义。
Since the well-differentiated matrix cells don't have the inhibitory effect on tumor cell growth, we predicted that some innate features of stem cells contribute to this effect of AFMSC.
由于成熟的基质细胞不存在抑制肿瘤增殖的作用，我们推测可能是AFMSC的内在特性决定了这种作用的发挥。
TIMP, MMP-2,1C AM were secreted by the tumor cells can boost the adhere of tumor cells and matrix remold and turn into the substance base of vasculogenic mimicry .
肿瘤细胞表达基质金属蛋白酶类物质和勃附分子说明了恶性黑色素瘤组织存在血管生成拟态形成的物质基础。
Tumor microenvironment is composed of mesenchymal cells and extracellular matrix components, which plays an important role in the growth, invasion and metastasis of tumor cells.
间质细胞与细胞外基质成分构成的肿瘤微环境对肿瘤细胞的生长、浸润和转移具有重要作用。
Methods Use immunohistochemistry method to detect the osteocalcin, bone sialoprotein and osteopontin expressions in tumor cells and matrix of 50 cases of osteosarcoma.
方法采用免疫组化方法检测OC、BSP、OPN在50例各型骨肉瘤肿瘤细胞、基质中的表达。
Objective: To study the relationship between expression of matrix metalloproteinase 2 (MMP 2) and biological behaviors and tumor metastases in breast cancer.
目的：研究乳腺癌中基质金属蛋白酶-2 (MMP - 2)的表达特点，探讨其与乳腺癌生物学行为及肿瘤转移的关系。
Objective To approach the expression of matrix metalloproteinase (MMP) -9 and its significance in breast carcinoma and corresponding non-tumor normal tissues.
目的探讨基质金属蛋白酶-9 (MMP - 9)在乳腺癌及癌旁正常组织中的表达及意义。
Purpose: to evaluate primarily the ability of urinary level of nuclear matrix protein 22 (NMP22) as a tumor marker for the diagnosis of original and recurrent bladder cancer.
目的：评估尿核基蛋白(NMP22)测定作为诊断初发性膀胱癌及复发性膀胱癌的临床应用价值。
Objective To investigate the expression of matrix metalloproteinase-2(MMP-2) in the VX2 hepatic tumor.
目的探讨在兔VX2肝癌模型上的金属蛋白酶-2（MMP-2）的表达特征及其意义。
The recent studies demonstrate that cytogenetic alterations, oncogenes, tumor suppressor genes, adhesion molecules and extracellular matrix proteins may play important roles in the process.
研究发现，细胞遗传学改变、癌基因、抑癌基因、黏附分子及细胞外基质蛋白在涎腺多形性腺瘤的恶变过程中均有一定的作用。
The recent studies demonstrate that cytogenetic alterations, oncogenes, tumor suppressor genes, adhesion molecules and extracellular matrix proteins may play important roles in the process.
研究发现，细胞遗传学改变、癌基因、抑癌基因、黏附分子及细胞外基质蛋白在涎腺多形性腺瘤的恶变过程中均有一定的作用。
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