Objective To study the relationship between carboxyl terminus region of EBV LMP1 and telomerase activation.
目的探讨EB病毒LMP1羧基端胞浆区与端粒酶活化的关系。
Objective To study the reverse effect on the malignant phenotype of human NPC cells CNE2 transfected with EBV-LMP1 antisense gene.
目的研究EB病毒LMP1反义基因对人鼻咽癌CNE2细胞恶性表型的逆转作用。
First, we utilized a protein array to examine the cytokine expression profiles, and eight cytokines were found to be upregulated by LMP1.
首先，以蛋白质微阵列做初步的检验，结果显示LMP1能促进鼻咽癌细胞株分泌八种细胞激素。
No expression of LMP1 was detected in all tumor specimens. CONCLUSION: EBV infection might be associated with colorectal carcinoma in Chinese.
以上标本中均未检测到LMP1的表达。结论：EBV与部分中国人结直肠癌相关。
The EBV latent membrane protein (LMP1) gene and nucleoantigen gene EBNA2 are virus-oncogene, which can induce malignant transformation of cells.
EBV潜伏膜蛋白基因LMP1和核抗原基因EBNA2是公认的导致细胞恶性转化的病毒癌基因。
Thus the strategy to combine the gene therapy of this targeting LMP1 gene with radiotherapy is expected to enhance the local control and long term effect.
针对该基因的靶向治疗联合放疗有望增加鼻咽癌的局部控制和远期疗效。
Conclusion EBV LMP1 is able to activate telomerase and this function is related to the carboxyl terminus region of LMP1, specially CTAR1 domain and CTAR2 domain.
结论EB病毒LMP1可活化端粒酶活性，这一功能与LMP1羧基端胞浆区，特别是其功能域ctar1和CTAR2密切相关。
Objective To assess the stability and variability of the LMP1 gene and protein in nude-mice transplanted tumor models of extranodal nasal type NK/T-cell lymphoma.
目的研究LMP1基因和蛋白在结外鼻型NK/T细胞淋巴瘤移植瘤模型传代组织中的稳定性和变异性。
The results showed that LMP1 up regulated the expression of some genes related to apoptosis and anti apoptosis, and down regulated the expression of some other genes of apoptosis and anti apoptosis;
结果表明：①LMP1介导细胞凋亡和抑制细胞凋亡的基因的表达，同时上调或下调某些与细胞凋亡相关基因的表达；
The results showed that LMP1 up regulated the expression of some genes related to apoptosis and anti apoptosis, and down regulated the expression of some other genes of apoptosis and anti apoptosis;
结果表明：①LMP1介导细胞凋亡和抑制细胞凋亡的基因的表达，同时上调或下调某些与细胞凋亡相关基因的表达；
应用推荐