It is with great regret that I accept your resignation.
接受你的辞呈，我感到非常遗憾。
It is with great pleasure that I welcome you to the new Museum of Industrial and Rural Life.
我非常高兴地欢迎你们来到新的工业农村生活博物馆。
It is with great pleasure for me to announce an appointment.
我非常荣幸向大家宣布一个任命通知。
Friends, it is with great pleasure that I introduce Mary to you.
朋友们，我很高兴介绍玛丽同你们认识。
It is with great regret that our department has to downsize to three people.
非常遗憾的是，我们的部门要减员至三人。
It is with great pleasure to meet you at Kuala Lumpur Presidential Conference.
很高兴于吉隆坡社长会议遇见您。
It is with great pride that I now declare the XVI International AIDS Conference officially open.
我非常自豪地宣布第十六届国际艾滋病大会正式开幕。
It is with great pleasure that I introduce to you Mr. Bill Gates, President of Microsoft Company.
请允许我荣幸地向各位介绍微软公司总裁比尔·盖茨先生。
It is with great pleasure that I introduce to you Mr. Bill Gates, President of Microsoft company.
请允许我荣幸地向各位介绍微软公司总裁比尔·盖茨。
So it is with great excitement that we announce the launch of the ParisTech OpenCourseWare project.
因此我们极为兴奋地宣布法国高科的开放式课程计画启动了。
It is with great pleasure that I extend a warm welcome to the Australian delegation led by Mr. Davis.
我非常愉快地向戴维斯先生率领澳大利亚代表团表示热烈的欢迎。
He wrote: "it is with great joy and emotion that I inform I have recently become father to a baby boy."
他写道：“我怀着非常喜悦和激动的心情向大家宣布：我做爸爸啦！”
Respected leaders, it is with great honor for me to have such an opportunity to introduce myself to you.
各位领导好！很荣幸有这样一个机会，让我相各位介绍我自己。
It is with great delight I AM joining My Beloved Son Michael of Nebadon in his Greatest Endeavour so far.
我是怀着巨大的喜悦而参与到我挚爱儿子—内巴顿(基督)迈克迄今为止最非比寻常的尽心投入之中。
It Is wIth great pleasure that I Introduce to you Mr. Stanley Young, assIstant Manager of General ElectrIc.
我很高兴向诸位介绍通用电器公司副经理，斯坦利·杨先生。
It is with great pleasure that DBR (Lafite), and ASC Fine Wines today announce a new partnership for the China market.
我非常荣幸地宣布罗斯柴尔德男爵拉菲集团与ASC 精品酒业在中国市场正式建立合作伙伴关系。
"It is with great sadness and a heavy heart that I have decided to end my six-year marriage to Ashton," says Moore in a statement.
黛米·摩尔在声明中说道：“对我来说结束与艾什顿六年的婚姻是非常悲伤和沉重的。”
It is with great pleasure that we are pleased to offer to you our new book, The LifeWave Experience, our official LifeWave Handbook!
这是很大的荣幸，我们很高兴提供给你们，我们的新书，“莱威经验”，我们官方正式的莱威手册！
It is with great sadness that Arsenal Football Club announces the death of Danny Fiszman after a long battle with illness. He was 66.
阿森纳足球俱乐部沉痛的宣布，丹尼·菲什曼在与疾病抗战过程中逝世，享年66岁。
It is with great interest that I read your comments. I am the author of the piece and wanted to respond to a few of the comments above.
很高兴能够读到你们的评论，我是这篇报道和照片的作者，在此想对上面的一些评论做出回应。
It is with great pleasure that we invite you to join us for the 3rd Atlantic Eye Symposium to be held in the beautiful city of Halifax.
我们非常高兴邀请您加入我们的研讨会在美丽的城市哈利法克斯举行的第三大西洋眼。
Your Excellencies, distinguished guests, my lords, ladies and gentlemen, it is with great pleasure that I welcome you tonight to this magnificent castle.
诸位阁下，贵宾们，勋爵们，女士们，先生们，我非常高兴在这里欢迎各位今晚到这座雄伟的城堡来。
Yoga IS so much more than that, and it is with great pleasure that I will do my best to open your eyes and your mind to what yoga is and what yoga could be.
瑜伽远远不止这些，我很乐意尽最大努力让你了解什么是瑜伽，让你明白瑜伽能让你达到什么境界。
It is with great sadness that I note the passing on Christmas eve of Samuel Huntington, long-time teacher, friend, and editorial board member of the American Interest.
当我得知亨廷顿在圣诞前夕仙去，悲从中来。亨廷顿是我的良师益友，他也是《美国利益》杂志的编委。
"It is with great sadness that we can confirm our beloved son, brother and friend George passed away peacefully at home over the Christmas period," his publicist said in a statement.
他的公关在一份声明中说，我们带着极度悲伤证实，我们深爱的儿子，兄弟和朋友乔治·迈克尔圣诞节期间在家中平静地去世了。
I must confess that it is with great hopes, joy and enthusiasm that I write you this email which I know and believe by faith that it must surely find you in good condition of health.
我必须承认，这封信抱着很大的希望，欢乐和热情，我给你写这封邮件，我知道，凭信心相信，它一定会找到身体健康的你。
Lord Bell, her spokesman, said: "it is with great sadness that Mark and Carol Thatcher announced that their mother Baroness Thatcher died peacefully following a stroke this morning."
撒切尔夫人的发言人贝尔表示：“马克和卡罗尔·撒切尔很悲伤地宣布，他们的母亲在今天早晨因为中风去世，她走得很平静。”
The full publicist statement today said: "it is with great sadness that we can confirm our beloved son, brother and friend George passed away peacefully at home over the Christmas period."
在今天公关发表的声明全文中称：“是的，我们深爱的儿子、兄弟和朋友乔治已于圣诞节期间在家中平静去世，这令我们非常悲伤。”
The full publicist statement today said: "it is with great sadness that we can confirm our beloved son, brother and friend George passed away peacefully at home over the Christmas period."
在今天公关发表的声明全文中称：“是的，我们深爱的儿子、兄弟和朋友乔治已于圣诞节期间在家中平静去世，这令我们非常悲伤。”
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